序贯疗法联合双歧杆菌三联活菌胶囊治疗胃溃疡并幽门螺杆菌感染的临床疗效

Sequential therapy combined with bifidobacterium triple viable capsules for gastric ulcer with Helicobacter pylori infection

目的探讨序贯疗法联合双歧杆菌三联活菌胶囊治疗胃溃疡并幽门螺杆菌(Hp)感染的临床疗效。方法选取三明市第二医院消化内科2016年6月-2018年6月收治的胃溃疡并Hp感染患者240例,根据治疗方法异同分成A组、B组、C组,每组80例。A组给予标准四联疗法(雷贝拉唑钠肠溶片+阿莫西林胶囊+克拉霉素片+胶体果胶铋)治疗,B组在A组基础上给予双歧杆菌三联活菌胶囊治疗,C组给予序贯疗法(雷贝拉唑钠肠溶片+左氧氟沙星胶囊+阿莫西林胶囊+克拉霉素片+胶体果胶铋+雷贝拉唑钠肠溶片)联合双歧杆菌三联活菌胶囊治疗,3组均连续治疗14 d。比较3组临床疗效、Hp根除率,治疗前后临床症状(腹痛、腹胀、反酸嗳气)评分,并观察3组不良反应发生情况。结果B组、C组总有效率高于A组(P<0.05)。B组、C组Hp根除率高于A组,C组Hp根除率高于B组(P<0.05)。治疗前3组腹痛、腹胀、反酸嗳气评分比较,差异无统计学意义(P>0.05);治疗后C组腹痛、腹胀、反酸嗳气评分低于A组、B组(P<0.05)。B组、C组不良反应发生率低于A组(P<0.05);B组、C组不良反应发生率比较,差异无统计学意义(P>0.05)。结论序贯疗法联合双歧杆菌三联活菌胶囊治疗胃溃疡并Hp感染的临床疗效确切,可提高Hp根除率,缓解临床症状,且安全性高。

Objective To investigate the clinical effect of sequential therapy combined with bifidobacterium triple viable capsules for gastric ulcer with Hp infection.Methods A total of 240 cases of patients with gastric ulcer and Hp were selected from June 2016 to June 2018 in the Department of Gastroenterology,the Second Hospital of Sanming City,which were divided into A group,B group and C group according to the differences and similarities of treatment methods,80 cases in each group.A group was treated with standard quadruple therapy(rabeprazole sodium enteric coated tablets+Amoxicillin Capsules+clarithromycin tablets+colloidal bismuth pectin),B group was treated with bifidobacterium triple viable capsules based on A group,and C group was treated with sequential therapy(rabeprazole sodium enteric coated tablets+levofloxacin capsules+Amoxicillin Capsules+clarithromycin tablets+colloidal bismuth pectin+rabeprazole sodium enteric coated tablets)combined with Bifidobacterium triple viable capsules.The three groups were treated for 14 days.The clinical efficacy,Hp eradication rate,clinical symptoms(abdominal pain,abdominal distention,acid regurgitation and belching)scores before and after treatment were compared among the three groups,and the adverse reactions were observed.Results The total effective rate of B group and C group was higher than A group(P<0.05).The Hp eradication rate of B group and C group was higher than A group,and C group was higher than B group(P<0.05).Before treatment,there was no significant difference in the scores of abdominal pain,abdominal distention and acid regurgitation between the three groups(P>0.05).After treatment,the B group and C group incidence rate of adverse reactions was lower than A group(P<0.05);there was no significant difference of incidence rate between B group and C group(P>0.05).Conclusion Sequential therapy combined with bifidobacterium triple viable capsules has a definite clinical effect for gastric ulcer with Hp infection,which can improve the eradication rate of Hp,relieve the clinical symptoms,and with high safety.