托伐普坦联合尿毒清颗粒治疗肾病综合征的临床效果

Clinical effect of tovaptan combined with Niaoduqing granules in the treatment of nephrotic syndrome

目的观察托伐普坦联合尿毒清颗粒治疗肾病综合征患者的临床效果。方法选择2017年8月-2018年12月四川省资阳市第一人民医院肾病内科诊治肾病综合征患者90例作为研究对象,依据随机数字表法将患者分为对照组(n=45)和观察组(n=45),入院后根据诊疗规范进行治疗,对照组给予托伐普坦,观察组在对照组基础上给予尿毒清颗粒,治疗1个月后,比较2组治疗前后的血肌酐、尿素氮、尿量、血红蛋白、血清白蛋白、钾离子和钙离子水平,记录不良反应发生情况。结果治疗1个月后,2组血肌酐与尿素氮水平均降低,且观察组降低幅度大于对照组(t/P=3.999/0.000、2.316/0.023);2组的尿量、血红蛋白和血清白蛋白均上升,且观察组上升幅度大于对照组(t/P=-11.320/0.000、-4.606/0.000、-3.068/0.003),2组治疗前后的钾、钙离子浓度均未发生明显变化(P>0.05);不良反应发生率比较差异亦无统计学意义(P>0.05)。结论使用托伐普坦联合尿毒清颗粒治疗肾病综合征患者,可以改善患者的肾功能,改善尿量和营养状态,稳定体内电解质水平,安全性良好。

Objective To observe the clinical effect of tovaptan combined with granules in the treatment of nephrotic syndrome.Methods From August 2017 to December 2018,90 patients with nephrotic syndrome were selected as the study object.Patients were divided into control group(n=45) and observation group(n=45).After admission,the patients were treated according to the standard of diagnosis and treatment.The control group was given tovaptan,and the observation group was given Niaoduqing granules based on the control group.After one month of treatment,the levels of serum creatinine,urea nitrogen,urine volume,hemoglobin,serum albumin,potassium ion and calcium ion were compared before and after treatment,and the adverse reactions were recorded.Results After treatment,the levels of serum creatinine and urea nitrogen decreased in both groups,and the reduction in the observation group was greater than that in the control group(t/P=3.999/0.000,2.316/0.023).Urine volume,hemoglobin,and serum albumin increased in both groups,and the increase in the observation group was greater than that in the control group(t/P=-11.320/0.000,-4.660/0.000,-3.068/0.003).There were no significant changes in potassium and calcium concentrations before and after treatment in the two groups(P>0.05),and there was no significant difference in the incidence of adverse reactions(P>0.05).Conclusion In the treatment of nephrotic syndrome patients,the combination of tovaptan and Niaoduqing granules can improve the renal function,improve the urine volume and nutritional status,stabilize the body electrolyte level,and have good safety.