乳腺癌分子分型与放射治疗相关性的研究进展

Progress of the relationship between molecular typing of breast cancer and radiotherapy

乳腺癌术后放疗可以降低局部复发率,且对于高危乳腺癌患者的长期生存有积极的影响。当前乳腺癌放射治疗的精准性主要依赖于不同的放疗技术、肿瘤的临床分期及病理类型。但随着乳腺癌研究的深入,要进一步提升乳腺癌术后放疗的精准性,乳腺癌本身的生物学特性应该得到重视。据相关文献报道,不同分子分型的乳腺癌其局部复发率有显著差异。因此乳腺癌的分子分型对放疗计划的制定有极为重要的指导意义。本文针对当前乳腺癌分子分型与肿瘤局部复发风险关系的相关研究以及乳腺癌分子分型指导放射治疗的临床进展作一综述。

Postoperative radiotherapy for breast cancer can reduce the local recurrence rate and has a positive effect on the long-term survival of high-risk breast cancer patients.The current accuracy of radiotherapy for breast cancer mainly depends on different radiotherapy techniques,clinical stage and pathological type of tumor.To further improve the accuracy of postoperative radiotherapy for breast cancer,the biological characteristics of breast cancer should be emphasized.According to relevant literature,local recurrence rate of breast cancer with different molecular types is significantly different.This article reviewed the recent research in the correlation between breast cancer molecular typing and the risk of local recurrence of the cancer.Meanwhile,the progress in the trial of radiation therapy assisted by the molecular typing was investigated.