摘要
双磷酸盐(bisphosphonates,BPs)等药物通过抗血管生成,同时抑制骨吸收,进而增强骨质被广泛应用于临床,但此类药常导致颌骨严重并发症,引起广泛关注。本文对药物相关性骨坏死(medication-related osteonecrosis of the jaw,MRONJ)研究进行总结,为此类疾病的临床治疗提供一定帮助。
The bisphosphonates(BPs)by inhibiting osteoclast activity and resistance to bone resorption to improve the effect of osteoporosis has been confirmed,but has gained wide attention as a severe side effect.In this paper,the studies of drug-related osteonecrosis of the jaw(MRONJ)were summarized,providing some help for the clinical diagnosis and treatment.
作者
杨涛
魏建华
雷德林
杨耀武
杨新杰
王艳
张春谊
魏丽
Yang Tao;Wei Jianhua;Lei Delin;Yang Yaowu;Yang Xinjie;Wang Yan;Zhang Chunyi;Wei Li(State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology,Shaanxi Clinical Research Center for Oral Diseases,Department of Head and Neck Tumor Surgery,School of Stomatology,the Fourth Military Medical University,Shaanxi Xi'an 710032,China)
出处
《现代肿瘤医学》
CAS
2020年第6期1039-1042,共4页
Journal of Modern Oncology
关键词
双磷酸盐
药物相关性
抗肿瘤
颌骨坏死
颌骨感染
bisphosphonates
medication-related
antineoplasms
jaw osteonecrosis
infection
