基于关联规则的中药白芷临床内服与外用应用特点分析

Analysis on Clinical Internal and External Application Characteristics of Chinese Materia Medica Radix Angelicae Dahuricae Based on Association Rules

目的:比较分析中国知网中含白芷的中药复方内服与外用用药规律,旨在为白芷的临床开发应用提供方向和理论支持。方法:检索中国知网(CNKI)数据库1960年1月1日至2019年2月25日的数据,以“白芷+临床”为主题,筛选临床中含有中药白芷内服与外用的相关文献,对单味中药的性味归经、药物类别等进行频次统计,并进行关联规则统计分析。结果:CNKI共得到125首含白芷复方,外用药中以白芷(53次,46.49%)、大黄(14次,12.28%)、甘草(11次,9.65%)用药频次相对较高。内服药中以白芷(72次,37.70%)、甘草(32次,16.75%)、川芎(28次,14.66%)排名前3。在用药类别上,二者均以解表药和清热药占比较重。药性统计中,均以温、辛类占比较高,归经统计中,均趋于归肝、肺经。结论:比较中华人民共和国药典,白芷临床内服使用时与国家标准有异曲同工之处;临床外用时与国家标准统计结果有所不同,需具体情况具体分析。

Objective:To compare and analyze the law of internal and external use of compound prescriptions of Chinese materia medica containing Radix Angelicae Dahuricae in CNKI,in order to provide direction and theoretical support for clinical development and application of Radix Angelicae Dahuricae.Methods:CNKI was used as the data source,taking“Radix Angelicae Dahuricae+clinical”as the theme,and the date“January 1,1960-February 25,2019”was used for advanced retrieval.Clinical literature related to internal and external use of Chinese materia medica Radix Angelicae Dahuricae was screened out.Frequency statistics on properties,flavors,channel tropism and categories of single kind of Chinese materia medica was conducted,and statistical analysis on association rules was conducted.Results:From CNKI,125 compound prescriptions containing Radix Angelicae Dahuricae were obtained.Among medicines for external use,frequencies of Radix Angelicae Dahuricae(53 times,46.49%),Radix et Rhizoma Rhei(14 times,12.28%)and Radix Glycyrrhizae(11 times,9.65%)were relatively high.Among medicines for internal use,Radix Angelicae Dahuricae(72 times,37.70%),Radix Glycyrrhizae(32 times,16.75%)and Rhizoma Ligustici Chuanxiong(28 times,14.66%)ranked the top 3.In terms of medication categories,both of them were mainly superficies-relieving medicines and heat-clearing medicines.In the statistics of medicinal properties,proportions of warm and pungent ones were higher.And in the statistics of channel tropism,they tended to return to liver and lung channels.Conclusion:Compared with Chinese pharmacopoeia,clinically internal use of Radix Angelicae Dahuricae is similar to the national standard.Clinically external use is different from the national standard′s statistical results,which needs to be specific analyzed.