摘要
患者围术期接受的手术或侵入性操作,常引发患者自身炎症反应,激发体内的免疫调控机制。为探讨围术期炎症与免疫反应调控的影响因素及机制,本综述从手术创伤、麻醉管理、迷走神经在围术期炎症反应中的作用,梳理围术期炎症反应调控的相关研究。探索围术期炎症调控的麻醉管理策略或干预手段,将有助于不断改善患者术后的临床结局。
During the perioperative period,when patients receive surgical or invasive therapies,it often triggers the patient's own inflammatory response and stimulates the immune regulation.In order to review the influencing factors and mechanism of perioperative inflammation response,the article explored the surgical trauma,anesthesia management,and the role of vagus nerve in perioperative inflammatory response.We believe that the through research into the anesthesia management strategies will help to illustrate the perioperative inflammatory immune regulation,which will definitely improve postoperative clinical outcome.
作者
程业
谢芳
薄禄龙
Cheng Ye;Xie Fang;Bo Lulong(College of Basic Medical Sciences,Naval Medical University,Shanghai,China;Faculty of Anesthesiology,Changhai Hospital,Naval Medical University,Shanghai,China)
基金
国家自然科学基金面上项目(81671887)
上海市优秀青年医学人才培养计划(2017YQ015)
上海市青年科技启明星计划(19QA1408500)
关键词
炎症
免疫反应
麻醉
迷走神经
Inflammation
Immune Response
Anesthesia
Vagus Nerve