羟基红花黄色素A改善心肌缺血再灌注损伤研究进展

Progress in Research on Myocardial Ischemia-reperfusion Injury Induced by Hydroxysafflor Yellow A

急性心肌梗死(AMI)可引起心源性休克甚至猝死,及时、有效的冠状动脉再灌注治疗可减缓病情发展,但无效的心肌缺血再灌注(I/R)可诱导心肌二次损伤,引起心肌内出血及其他并发症增加致死率,严重影响人们的生活质量。心肌缺血再灌注会引起氧自由基的堆积、细胞内Ca 2+超载、线粒体膜通透性转换孔开放等。羟基红花黄色素A(HSYA)是红花中有效化学成分之一,多项研究表明其可通过抗氧化应激损伤、抗细胞凋亡、保护线粒体及扩张血管等有效减缓心肌缺血再灌注损伤。近年来国内外对HSYA心血管系统药理作用的研究逐步深入,本文对国内外心肌缺血再灌注损伤相关文献进行了整理,并对HSYA在临床上的进一步应用进行了展望。

Acute myocardial infarction(AMI)can cause cardiogenic shock or even sudden death.Timely and effective coronary reperfusion can slow the progression of the disease,but ineffective myocardial ischemia-reperfusion(I/R)can induce secondary myocardial injury.Intramyocardial hemorrhage and other complications increase the mortality rate,which seriously affects people s quality of life.Myocardial ischemia-reperfusion causes accumulation of oxygen free radicals,intracellular Ca 2+overload,and opening of mitochondrial membrane permeability transition pores.Hydroxysafflor yellow A(HSYA)is one of the effective chemical constituents in safflower.Many studies have shown that it can effectively alleviate myocardial ischemia and reperfusion through anti-oxidative stress damage,anti-apoptosis,protection of mitochondria and dilation of blood vessels.damage.In recent years,the research on the pharmacological effects of HSYA cardiovascular system has been gradually deepened.The literatures on myocardial ischemia-reperfusion injury at home and abroad have been collated,and the further application of HSYA in clinical practice is prospected.