脑梗死患者颅内外动脉狭窄部位与ox-LDL水平的相关性研究

Corelation between ox-LDL level and the distribution of intracrainal and extracranial atherosclerosesin in patients with cerebral infarction

目的探讨颅内外中重度大动脉粥样硬化型脑梗死患者血清氧化修饰低密度脂蛋白(ox-LDL)水平与动脉粥样硬化部位的相关性。方法采用酶联免疫吸附法(ELISA)检测120例颅内外中重度大动脉粥样硬化型脑梗死患者的血清ox-LDL水平,并通过全脑血管造影(DSA)分析其与颅内外动脉狭窄及闭塞部位的关系。结果颅内动脉狭窄组和颅外动脉狭窄组患者ox-LDL水平高于颅内外并存狭窄组,尤其以颅内动脉狭窄组为著(P<0.05)。其中大脑前动脉狭窄的发生率最高,其次为颈内动脉颅外段及颈总动脉。Spearson相关分析显示动脉狭窄患者ox-LDL水平与血管狭窄率呈正相关。结论ox-LDL升高是造成脑梗死患者颅内动脉狭窄率高的主要原因,ox-LDL水平升高是动脉粥样硬化性狭窄的独立危险因素。

Objective To investigate the correlation between serum oxidatively modified low-density lipoprotein(ox-LDL) levels and the site of cranial atherosclerosis in patients with cerebral infarction.Methods Enzyme-linked immunosorbent assay(ELISA) was used to detect the serum ox-LDL levels in 120 patients with intracranial and extracranial atherosclerotic cerebral infarction,and the correlation between ox-LDL level and intracranial and external arterial stenosis and occlusion site was analysed by(DSA).Results The levels of ox-LDL in patients with intracranial artery stenosis and extracranial artery stenosis were higher than those in the intracranial and extracranial stenosis,especially in the intracranial group(P<0.05).Conclusion High ox-LDL level is the main cause of high rate of intracranial artery stenosis in patients with cerebral infarction,and high ox-LDL level is an independent risk factor for atherosclerotic stenosis.