肌减少性肥胖与代谢综合征的关系

Corelation between sarcopenic obesity and metabolic syndrome

目的探讨肌减少性肥胖与代谢综合征的关系,为代谢综合征的防治提供理论依据。方法选取在体检中心体检≥18岁并自愿接受体成分分析检测的1825例人群为研究对象。根据是否为肌减少症和肥胖将其分为正常组(850例)、肌减少症组(136例)、肌减少性肥胖组(472例)和肥胖组(367例),进行问卷调查、体格测量、体成分分析检测和生化指标测定。结果不同性别的4组人群各重要人体体成分指标差异均有显著性(P<0.01);无论男性女性,肌减少性肥胖组体脂百分比、内脏脂肪面积、腰臀比和体质指数高于其他组,而肌肉量、四肢骨骼肌质量和骨骼肌指数均低于肥胖组,差异均有显著性(P<0.01);本组共检出代谢综合征272例(14.9%),其中肌减少性肥胖组检出率为31.6%.多因素Logistic回归结果显示,调整性别、年龄混杂因素后,肌减少性肥胖组、肌减少症组和肥胖组相对于正常组,其发生代谢综合征的风险均有统计学意义,OR值分别为7.860(95%CI:5.412~11.416)、2.477(95%CI:1.333~4.604)和3.858(95%CI:2.539~5.863)。结论肌减少性肥胖与代谢综合征存在相关性,应积极防治肌减少性肥胖预防代谢综合征的发生。

Objective To investigate the corelation between sarcopenic obesity and metabolic syndrome,in order to provide the scientific basis for the prevention and treatment of metabolic syndrome.Methods One thousand eight hundred and twenty-five adults over 18 years old who had undergone physical examination and voluntary body composition analysis in Weifang People’s Hospital were selected and classified into normal group(850 cases),sarcopenia group(136 cases),sarcopenic obesity group(472 cases) and obesity group(367 cases) according to whether they were sarcopenia or obesity body types.Questionnaire survey,physical measurement,body composition analysis and biochemical index determination were carried out.The differences of body composition index and metabolic syndrome detection rate were compared among the groups.Results Differences in body composition indexes between the four groups of different sexes are statistically significant among the four groups(P<0.01).No matter male or female,the percentage of body fat,visceral fat area,waist-hip ratio and bady mass index in sarcopenic obesity group were higher than those in other groups,while the muscle mass,appendicular skeletal muscle mass and skeletal muscle index were lower than those in obesity group(P<0.01).A total of 272 cases(14.9%) of metabolic syndrome were detected.The detection rates of metabolic syndrome in sarcopenic obesity group was 31.6%.The multivariate logistic regression analysis showed that sarcopenic obesity group,sarcopenia group and obesity group was significantly higher than that in the normal group after adjusting the factors of gender and age,the OR values were 7.860(95%CI:5.412~11.416),2.477(95%CI:1.333~4.604) and 3.858(95%CI:2.539~5.863),respectively.Conclusion There is a correlation between sarcopenic obesity and metabolic syndrome,and preventions of sarcopenia obesity should be actively performed.