沙利度胺联合泼尼松治疗2型麻风反应临床观察

Clinical Observation of Thalidomide Combined with Prednisone in the Treatment of Type 2 Leprosy Reaction

目的:观察沙利度胺联合泼尼松治疗2型麻风反应的临床效果。方法:选取2014年8月-2016年8月笔者所在医院收治的2型麻风反应患者54例,按照随机数字表法将其分为对照组(27例)和观察组(27例)。对照组给予泼尼松单独用药治疗,观察组应用沙利度胺联合泼尼松治疗。比较两组临床疗效与不良反应发生情况。结果:观察组治疗总有效率为92.59%,高于对照组的74.07%,差异有统计学的意义(P<0.05)。观察组不良反应发生率为25.93%,对照组不良反应发生率为22.22%,两组比较差异无统计学意义(P>0.05)。结论:沙利度胺联合泼尼松治疗2型麻风反应的临床效果比较显著,联合用药较为安全,值得在临床上推荐应用。

Objective:To observe the clinical effect of Thalidomide combined with Prednisone in the treatment of type 2 leprosy reaction.Method:A total of 54 patients with type 2 leprosy reaction admitted in our hospital from August 2014 to August 2016 were selected and divided into the control group(27 cases) and the observation group(27 cases) according to the random number table method.The control group was treated with Prednisone alone,while the observation group was treated with Thalidomide combined with Prednisone.The clinical effect and adverse reactions of the two groups were compared.Result:The total effective rate of the observation group was 92.59%,which was higher than 74.07% of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 25.93% and 22.22% in the control group.There was no significant difference between the two groups(P>0.05).Conclusion:The clinical effect of Thalidomide combined with Prednisone in the treatment of type 2 leprosy reaction is relatively significant,and the combination of drugs is relatively safe,which is worthy of clinical recommendation.