急性脑梗死合并脑微出血患者行静脉溶栓治疗的效果及预后价值

Effect and prognostic value of intravenous thrombolytic therapy in patients with acute cerebral infarction complicated with cerebral microbleeds

目的探讨急性脑梗死合并脑微出血患者行静脉溶栓治疗的效果及预后价值。方法选取我院2017年1月至2018年1月收治的98例急性脑梗死合并脑微出血患者作为研究对象,采用随机数字法将其分为常规组(49例,常规治疗)和静脉溶栓治疗组(49例,常规治疗+静脉溶栓治疗)。比较两组患者的临床疗效。结果治疗前,两组的美国国立卫生研究院卒中量表(NIHSS)、Barthel指数(BI)、格拉斯哥昏迷指数(GCS)评分比较,差异均无统计学意义(P>0.05);治疗2周后,两组的NIHSS评分均降低,BI、GCS评分均升高,且静脉溶栓治疗组明显优于常规组,差异具有统计学意义(P<0.05)。静脉溶栓治疗组的临床治疗总有效率明显高于常规组,差异具有统计学意义(P<0.05)。静脉溶栓治疗组的并发症总发生率明显低于常规组,差异具有统计学意义(P<0.05)。结论急性脑梗死合并脑微出血患者行静脉溶栓治疗的效果显著,可改善患者预后,值得临床推广应用。

Objective To investigate the effect and and prognostic value of intravenous thrombolytic therapy in patients with acute cerebral infarction complicated with cerebral microbleeds. Methods A total of 98 patients with acute cerebral infarction complicated with cerebral microbleeds admitted in our hospital from January 2017 to January 2018 were selected as the research objects and divided into routine group(49 cases, routine treatment) and intravenous thrombolytic therapy group(49 cases, routine treatment +intravenous thrombolytic therapy) by random number method. The clinical efficacy of the two groups were compared. Results Before treatment, there were no significant differences in the scores of National Institutes of Health Stroke Scale(NIHSS), Barthel index(BI) and Glasgow coma scale(GCS) between the two groups(P>0.05);after 2 weeks of treatment, the NIHSS score in the two groups decreased, BI and GCS scores increased,and those in the intravenous thrombolytic therapy group were significantly better than the routine group( P <0.05). The total effective rate of clinical treatment in the intravenous thrombolytic therapy group was significantly higher than that in the routine group(P <0.05). The total incidence of complications in the intravenous thrombolytic therapy group was significantly lower than that in the routine group(P<0.05). Conclusion Intravenous thrombolytic therapy in patients with acute cerebral infarction complicated with cerebral microbleeds has a significant effect, it can improve the prognosis of patients, which is worthy of clinical application and promotion.