前列地尔治疗早期糖尿病肾病患者的临床效果及其对血管内皮功能的影响

Clinical effect of alprostadil in the treatment of patients with early diabetic nephropathy and its influence on vascular endothelial function

目的探讨前列地尔治疗早期糖尿病肾病的临床效果及其对患者血管内皮功能的影响。方法选取2017年12月至2018年12月我院收治的82例早期糖尿病肾病患者为研究对象,按照信封法将其分为常规组和前列地尔组,各41例。常规组给予常规治疗,前列地尔组在常规组基础上采用前列地尔治疗。比较两组治疗前、治疗2周后的血清炎性因子指标、血管内皮功能指标及临床治疗效果。结果治疗前,两组的TGF-β1、IL-6、TNF-α、hs-CRP水平比较,差异无统计学意义(P>0.05);治疗2周后,两组的TGF-β1、IL-6、TNF-α、hs-CRP水平均降低,且前列地尔组低于常规组,差异具有统计学意义(P<0.05)。前列地尔组的治疗总有效率显著高于常规组,差异具有统计学意义(P<0.05)。治疗前,两组的ET-1、CEC、sICAM-1、vWF水平比较,差异无统计学意义(P>0.05);治疗2周后,两组的ET-1、CEC、sICAM-1、vWF水平均降低,且前列地尔组低于常规组,差异具有统计学意义(P<0.05)。结论前列地尔治疗早期糖尿病肾病的临床效果及对患者血管内皮功能的影响显著,值得临床推广应用。

Objective To investigate the clinical effect of alprostadil in the treatment of early diabetic nephropathy and its influence on vascular endothelial function of patients. Methods From December 2017 to December 2018, 82 patients with early diabetic nephropathy admitted in our hospital were selected as the study objects and divided into routine group and alprostadil group according to the envelope method, with 41 cases in each group. The routine group was given routine treatment, and the alprostadil group was given alprostadil treatment on the basis of the routine group. The serum inflammatory factors, vascular endothelial function before and 2 weeks after treatment and clinical therapeutic effects were compared between the two groups.Results Before treatment, there were no significant differences in the levels of TGF-β1, IL-6, TNF-α and hs-CRP between the two groups(P>0.05);after 2 weeks of treatment, the levels of TGF-β1, IL-6, TNF-α and hs-CRP in the two groups decreased,and those in the alprostadil group were lower than the routine group, the differences were statistically significant(P<0.05). The total effective rate of treatment in the alprostadil group was significantly higher than that in the routine group, the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in the levels of ET-1, CEC, sICAM-1 and vWF between the two groups(P>0.05);after 2 weeks of treatment, the levels of ET-1, CEC, sICAM-1 and vWF in the two groups decreased, and those in the alprostadil group were lower than the routine group, the differences were statistically significant(P<0.05). Conclusion Alprostadil has significant effects on the treatment of early diabetic nephropathy and vascular endothelial function of patietns, which is worthy of clinical promotion and application.