羟乙基淀粉130/0.4氯化钠注射液对剖宫产产妇及新生儿的影响

Effects of hydroxyethyl starch 130/0.4 and sodium chloride injection on parturient undergoing cesarean section and neonates

目的探讨羟乙基淀粉130/0.4氯化钠注射液对剖宫产产妇及新生儿的影响。方法将在我院行腰-硬联合麻醉剖宫产术的198例产妇采用简单随机抽样法将其分为观察组与对照组,每组99例。对照组给予乳酸钠林格注射液,观察组给予羟乙基淀粉130/0.4氯化钠注射液,比较两组的应用效果。结果麻醉后15 min、胎儿娩出时,观察组产妇MAP高于对照组,HR低于对照组(P<0.05)。观察组新生儿脐动脉以及脐静脉PaO2高于对照组,PaCO2低于对照组(P<0.05)。观察组产妇术中低血压、术后恶心呕吐发生率均低于对照组(P<0.05)。结论羟乙基淀粉130/0.4氯化钠注射液应用于剖宫产术,有利于术中产妇生命体征稳定、预防低血压的发生以及改善新生儿血气指标。

Objective To explore the effects of hydroxyethyl starch 130/0.4 sodium chloride injection on parturient undergoing cesarean section and neonates. Methods A total of 198 cases of parturients undergoing cesarean section under combined spinal and epidural anesthesia in our hospital were divided into observation group and control group by simple random sampling method, with 99 cases in each group. The control group was given sodium lactate ringer’s injection, while the observation group was given hydroxyethyl starch 130/0.4 sodium chloride injection. The application effects of the two groups were compared. Results At 15 minutes after anesthesia and when the baby is delivered, the MAP of parturient in the observation group were higher than those in the control group, and HR were lower than those in the control group(P<0.05).The PaO2 of umbilical artery and umbilical vein of neonates in the observation group were higher than those in the control group, and the Pa CO2 were lower than those in the control group(P<0.05). The incidence rates of intraoperative hypotension and postoperative nausea-vomiting of parturient in the observation group were lower than those in the control group(P<0.05).Conclusion The application of hydroxyethyl starch 130/0.4 sodium chloride injection in cesarean section is beneficial to the stability of vital signs, the prevention of hypotension of parturient and the improvement of blood gas indexes of neonates.