摘要
肿瘤坏死因子样弱凋亡诱导蛋白(TWEAK)是肿瘤坏死因子(TNF)超家族成员,通过作用于唯一受体成纤维细胞生长因子14(Fn14)调控细胞的增殖、分化和迁移等多种生命活动。近来研究表明,TWEAK/Fn14信号可以作用于多种干细胞,如肝干细胞、神经干细胞和间充质干细胞等,通过影响其增殖与分化的能力,干预组织的修复与再生。对该领域的研究进行综述,将有助于揭示TWEAK/Fn14信号调控干细胞增殖与分化的作用与机制,并为干细胞在疾病发生机制等基础研究、细胞治疗和组织工程等临床医学研究提供新的方向。
Tumor necrosisfactor(TNF)-like weak inducer of apoptosis(TWEAK)is a member of TNF superfamily,which plays an important role in the regulation of cell proliferation,differentiation and migration via its sole receptor,fibroblast growth factor inducible 14(Fn14).Recent studies have indicated that TWEAK/Fn14 signals act on a wide variety of stem cells such as hepatic stem cells,neural stem cells and mesenchymal stem cells,which intervene tissue repair and regeneration by affecting the proliferation and differentiation of stem cells.Here we review recent advances in studies,which would conduce to revealing the role of TWEAK/Fn14 signals in regulating stem cells'proliferation and differentiation as well as the mechanisms,and proposing new directions for stem cells in basic researches such as the pathogenesis of some diseases,and clinical researches such as cell therapies and tissue engineering.
作者
延祝
夏育民
Yan Zhu;Xia Yumin(Department of Dermatology,the Second Affiliated Hospital,Xi'an Jiaotong University,Xi'an 710004,China)
出处
《中华细胞与干细胞杂志（电子版）》
2020年第1期57-62,共6页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
国家自然科学基金(81630081)。
