Th1/Th2失衡与多囊卵巢综合征

Th1/Th2 imbalance and polycystic ovary syndrome

多囊卵巢综合征(PCOS)是育龄期女性常见的内分泌代谢紊乱性疾病。其发病机制尚未明确,越来越多研究表明,PCOS患者体内存在免疫功能紊乱。辅助性T细胞1型(Th1)与辅助性T细胞2型(Th2)介导体内细胞及体液免疫应答,两者相互调节又相互制约。正常情况下,机体内Th1/Th2处于平衡状态。研究发现,PCOS以Th1/Th2平衡向Th1偏移为主,可引起代谢紊乱、排卵障碍等,提示PCOS患者免疫平衡的打破可能是造成并发症产生的重要原因。目前,临床上通过使用药物平衡Th1、Th2细胞状态来改善临床症状。

Polycystic ovary syndrome(PCOS)is a common endocrine and metabolic disorder in women of reproductive age.The pathogenesis of PCOS is not clear,more and more studies show that PCOS patients have immune dysfunction.Helper T cell type 1(Th1)and helper T cell type 2(Th2)mediate cellular and humoral immune responses in vivo,and they regulate and restrict each other.Normally,Th1/Th2 is in equilibrium in the body.It is found that PCOS shifts from Th1/Th2 balance to Th1,which can cause metabolic disorder and ovulation disorder.It suggests that the break of immune balance in PCOS patients may be the cause of complications.Currently,drugs are used to balance Th1 and Th2 cell states to improve clinical symptoms.