寿胎丸化裁联合西药治疗复发性流产Meta分析

Meta-analysis of Modified Shoutai Pills Combined with Western Medicine for Recurrent Spontaneous Abortion

目的:系统评价寿胎丸化裁联合西药对复发性流产患者妊娠结局的影响。方法:电子检索PubMed、EMBASE、Cochrane Library、中国知网、维普期刊数据库、中国生物医学文献数据库及万方数据库,从建库至2018年9月发表的相关文献。由2名研究员各自独立严格进行纳入研究的质量评价和资料提取,对符合要求的随机对照试验用RevMan5.2软件进行Meta分析,用TSA v0.9软件进行试验序贯分析。结果:纳入文献14篇,共纳入1034例样本量,其中使用常规西药治疗的有516例,寿胎丸化裁联合常规西药治疗的有518例。与常规西医疗法比较,寿胎丸化裁联合西药治疗总有效率明显较优[OR=5.69,95%CI(3.83~8.48),P<0.00001],再次妊娠保胎成功率显著提高[OR=3.23,95%CI(92.45~4.25),P<0.00001]。结论:寿胎丸化裁联合西药治疗复发性流产疗效优于常规西药治疗。

Objective:To systematically evaluate the effect of modified Shoutai pills combined with western medicine on pregnancy outcome in patients with recurrent spontaneous abortion.Methods:Electronically searched PubMed,EMBASE,Cochrane Library,China national knowledge infrastructure,VIP periodical database,China biomedical literature database and Wanfang database.For the related literatures published from the time of database establishment to September in 2018,the quality evaluation and data extraction of the included studies was carried out by two researchers respectively,independently and strictly,Performed a Meta-analysis on the randomized controlled trials accorded with requirement by RevMan5.2 software and conducted the trial sequential analysis by TSA v0.9 software.Results:14 literatures and a total of 1034 sample sizes were included,among which 516 cases were treated with routine western medicine and 518 cases were treated with modified Shoutai pills combined with western medicine.Compared with the routine western medicine therapy,the total effective rate in the treatment which received modified Shoutai pills combined with western medicine was obviously better[OR=5.69,95%CI(3.83~8.48),P<0.00001],and the success rate of the secondary pregnancy was significantly improved[OR=3.23,95%CI(92.45~4.25),P<0.00001].Conclusion:The curative effect of the application of modified Shoutai pills combined with western medicine for recurrent spontaneous abortion is better than that of routine western medicine.