隔药灸联合雷诺考特对持续性中重度过敏性鼻炎患者临床症状及睡眠质量的影响

Herbal cake-partitioned moxibustion combined with Rhinocort spray is superior to Rhinocort spray alone in improving symptoms of moderate-severe allergic rhinitis patients

目的:观察隔药灸联合雷诺考特鼻喷剂对持续性中重度过敏性鼻炎(AR)患者临床症状、睡眠质量和生活质量的影响。方法:将67例持续性中重度AR患者随机分为观察组35例和对照组32例。观察组采用隔药灸联合雷诺考特鼻喷剂治疗,对照组单独应用雷诺考特鼻喷剂治疗,共治疗4周。分别在治疗前、治疗后及随访时比较两组AR患者症状视觉模拟量尺(VAS)、鼻结膜炎生活质量问卷(RQLQ)和匹兹堡睡眠质量量表(PSQI)评分,并评价两组患者的临床疗效。结果:与治疗前比较,治疗后及随访时两组VAS、RQLQ评分均显著降低(P<0.05),观察组PSQI评分显著下降(P<0.05);与对照组比较,观察组治疗后RQLQ及PSQI评分显著降低(P<0.05),观察组随访时VAS、RQLQ、PSQI评分均显著降低(P<0.05)。观察组总有效率为85.7%(30/35),显著高于对照组的71.9%(23/32,P<0.05)。结论:隔药灸联合雷诺考特鼻喷剂可有效改善持续性中重度AR患者的临床症状、睡眠质量和生活质量,远期疗效稳定,与单独应用雷诺考特鼻喷剂比较,其在改善临床症状、睡眠质量和生活质量方面具有优势。

Objective To observe the clinical effect of herbal cake-partitioned moxibustion combined with Rhinocort spray in the treatment of symptoms,sleep quality and daily life quality of patients with moderate-severe allergic rhinitis(AR).Methods A total of 67 patients with persistent moderate-severe AR were recruited in the present study and randomized into a treatment group(n=35)and a control group(n=32).The patients in the treatment group were treated by herbal cake-partitioned moxibustion(applied to Dazhui[GV14],and bilateral Feishu[BL13],Shenshu[BL23]and Zhiyang[GV9],3 moxacones/time,once every other day)plus Rhinocort spray(once in the morning and evening separately,256!g/d),and patients in the control group treated by Rhinocort spray alone(the same to that mentioned above).All the treatments were given for4 weeks.The therapeutic effect was evaluated with reference to the"Principles and Recommended Schemes for Diagnosis and Treatment of AR"formulated by Otolaryngology Branch of Chinese Medical Association before and after the treatment.The severity of symptoms of AR was assessed by using visual analogue scale(VAS),the life quality of nasal conjunctivitis assessed using"Rhino-conjunctivitis Quality of Life Questionnaire(RQLQ)",and the sleep quality assessed using"Pittsburgh Sleep Quality Index(PSQI)"before and after the treatment,followed by 3 months’follow-up survey.Results After the treatment,the VAS and RQLQ scores in both groups and PSQI of the treatment group were significantly decreased in comparison with their own base-line levels of pre-treatment in each group(P<0.05).The RQLQ and PSQI in the treatment group were substantially lower than those in the control group(P<0.05).No marked difference was found between the two groups in VAS(P>0.05).Follow-up survey showed that the VAS and RQLQ scores in both groups and PSQI of the treatment group were still significantly lower than those of pre-treatment in each group(P<0.05),and the VAS,RQLQ and PSQI scores of the treatment group were significantly lower than those of the control group(P<0.05).After 4 weeks’treatment,of the 32 and 35 AR patients in the control and treatment groups,7 and 16 experienced marked improvement,16 and 14 were effective,and 9 and 5 failed,with the effective rate being 71.9%and 85.7%,respectively.The effective rate of the treatment group was significantly superior to that of the control group(P<0.05).Conclusion Herbal cake-partitioned moxibustion combined with Rhinocort spray has a good therapeutic effect in improving symptoms,sleep and quality of life in patients with persistent moderate-severe AR,which is obviously superior to that of Rhinocort spray alone in improving sleep and quality of life.