不同间隔时间穴位埋线干预代谢综合征的对比研究

Clinical effect of acupoint thread-embedding therapy at different intervals in the intervention of metabolic syndrome

目的:观察不同时间间隔穴位埋线对代谢综合征(MS)的疗效,以期寻找最佳治疗间隔时间。方法:将MS患者随机分为治疗1组35例(脱落4例)和治疗2组35例(脱落3例)。两组均于中脘、梁门(双)、滑肉门(双)、天枢(双)、带脉(双)、关元、大肠俞(双)、脾俞(双)、足三里(双)、阴陵泉(双)、丰隆(双)穴进行埋线治疗,治疗1组间隔时间为7d,治疗2组间隔时间为14d,两组均以42d为1个疗程,共治疗2个疗程。分别于治疗前后测量腰围(WC)、臀围(HC)、腰臀比(WHR)、体质量指数(BMI),血中甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、空腹血糖(FPG)及糖化血红蛋白(Hb1Ac)含量,记录不良反应出现情况。结果:与本组治疗前比较,两组WC、HC、WHR、BMI及血液TG、LDL-C、FPG、Hb1Ac含量均显著降低(P<0.05),两组HDL-C显著升高(P<0.05)。治疗后,与治疗1组比较,治疗2组WC、WHR、BMI、TG、LDL-C、FPG、Hb1Ac显著升高(P<0.05),HDL-C显著降低(P<0.05)。两组不良反应率差异无统计学意义(P>0.05)。结论:在保证疗效及安全性的前提下,临床采用穴位埋线干预代谢综合征的优势治疗间隔时间为7d。

Objective To investigate the clinical effect of acupoint thread-embedding therapy at different intervals in the treatment of metabolic syndrome,and to find the optimal treatment interval.Methods A total of 70 patients with metabolic syndrome were randomly divided into treatment group 1(n=35)and treatment group 2(n=35).Both groups were given acupoint thread-embedding therapy at Zhongwan(CV12),bilateral Liangmen(ST21),bilateral Huaroumen(ST24),bilateral Tianshu(ST25),bilateral Daimai(GB26),Guanyuan(CV4),bilateral Dachangshu(BL25),bilateral Pishu(BL20),bilateral Zusanli(ST36),bilateral Yinlingquan(SP9),and bilateral Fenglong(ST40),and the treatment interval was 7 dfor treatment group 1 and 14 dfor treatment group 2.Each course of treatment was 42 d,and both groups were treated for 2 courses.Waist circumference(WC),hip circumference(HC),waist-hip ratio(WHR),body mass index(BMI),serum triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),and glycosylated hemoglobin(Hb1Ac)were measured before and after treatment to analyze clinical outcome,and adverse reactions were recorded.Results After treatment,both groups had significant reductions in WC,HC,WHR,BMI,TG,LDL-C,FPG and Hb1Ac(P<0.05)and a significant increase in HDL-C(P<0.05).Compared with treatment group 1,treatment group 2 had significant increases in WC,WHR,BMI,TG,LDL-C,FPG and Hb1Ac(P<0.05)and a significant reduction in HDL-C(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Under the premise of ensuring efficacy and safety,an interval of 7 dis the optimal interval for acupoint thread-embedding therapy in the clinical intervention of metabolic syndrome.