灸法治疗肿瘤的免疫机制研究进展

Advances in research on immune mechanism of moxibustion for treating tumor

灸法在临床中已广泛应用于肿瘤的治疗,针对灸法治疗肿瘤的机制研究也很多。本文通过梳理灸法治疗肿瘤的相关机制研究,从细胞、分子、基因层面,从免疫调节、神经-体液-内分泌方面进行总结,试阐述灸法治疗肿瘤的研究进展。通过文献梳理显示,艾灸可以调动机体免疫系统,刺激免疫细胞上升,调节细胞因子的表达,促使部分利于免疫作用的因子正向表达,部分抑制免疫作用的因子负向表达。同时艾灸可调控免疫相关蛋白及其他免疫相关成分的表达,从而促进免疫系统的自我调节。

Treatment of tumors,especially the malignant tumors,is a world-class medical problem and still plagues clinicians and medical scientists a lot nowadays.Moxibustion therapy has been used in the treatment of tumors in clinic practice for many years and the related mechanism researches have achieved a lot of achievements.In the present paper,we reviewed researches on moxibustion treatment for tumor from the self-regulation of the immune system in patients and animal models.Outcomes display that moxibustion therapy has an action in resisting tumors by 1)regulating innate immune defensive function and enhancing adaptive immunity(by up-regulating activities of natural killer[NK]cells,and phagocytic function of macrophages),2)stimulating cellular immunity(by increasing the ratio of CD4^+/CD8^+,lymphocyte transformation rate,etc.),and B lymphocyte-mediated humoral immunity(via regulating contents of IgG,IgA,IgM,etc.),3)modulating levels of cytokines as interleukins,interferons,tumor necrosis factor superfamily colony stimulating factor,chemokine growth factor,vascular endothelial growth factor,VEGF,etc.,4)regulating expression of many related proteins and genes,and 5)regulating related hormones,neurotransmitters,intracellular kinases signaling,etc.,and other immune-related components.