表观遗传学在心力衰竭中的最新研究进展

Recent Advances of Epigenetics in Heart Failure

心力衰竭(HF)是各类心血管病的终末阶段,患病率和死亡率较高,严重危害我国人民身体健康。目前已知的传统治疗方案不能满足临床对HF的治疗需求,因此探究HF新的致病机制、寻找新的治疗策略和药物靶点具有重要意义。表观遗传学未涉及基因序列的改变,却可以在不同的个体中稳定遗传,它受到基因与环境相互作用,产生DNA甲基化、组蛋白修饰等改变。本文从表观遗传学角度总结和探讨了HF的研究新进展。

Heart failure(HF)is the terminal stage of cardiovascular diseases and has long been one of the most deadly condition due to its high morbidity and mortality.Since the currently available treatment options cannot meet the clinical needs,new therapeutic strategies for HF should be actively explored.Epigenetics does not involve the changes of genetic sequences but focuses on the stable inheritance of genes in different individuals.It is affected by the interaction between genes and environments,which may result in DNA methylation,histone modification,and other changes.This article summarizes the recent research advances in epigenetics in HF.