微生物在精神分裂症发病机制的研究现状

Status of research on microorganisms in pathogenesis of schizophrenia

脑和肠道微生物群之间的相互作用逐渐被揭示。目前已经提出脑-肠轴失调和异常与各种中枢神经系统疾病有关。精神分裂症是一种病因不明的严重精神障碍。最近研究表明,肠道微生物的组成和数量变化会通过肠道菌群-肠-脑轴影响人类的认知和社会行为,这意味着肠道菌群在精神分裂症患者中可能起着重要的作用,并有望成为精神分裂症新的治疗靶点。本文综述了肠道菌群与精神分裂症相关性的研究进展,为预防和治疗精神分裂症等精神障碍类疾病提供了理论依据。

The interaction between the brain and intestinal microbiota has been gradually revealed, and it has been proposed that brain-gut axis disorders and abnormalities are related to various central nervous system diseases. Schizophrenia is a serious mental disorder with unknown etiology. Recent studies have shown that changes in the composition and quantity of intestinal microbial flora can affect human cognition and social behavior through the intestinal flora-gut-brain axis, which means that intestinal flora may play a role in patients with schizophrenia, and is expected to become a new therapeutic target for schizophrenia. This article reviews the progress in research on the relationship between intestinal flora and schizophrenia, and provides a theoretical basis for the prevention and treatment of mental disorders such as schizophrenia.