尿液外泌体作为泌尿系统肿瘤分子标志物的研究进展

Advances in the study of urinary exosomes as biomarkers of genitourinary tumors

外泌体是由包括肿瘤细胞在内的多种细胞分泌的膜性小囊泡,性状稳定,可反映来源细胞的生理/病理状态,是肿瘤早期诊断和判断预后的分子标志物的良好来源。尿液外泌体直接来源于泌尿系统,对泌尿系统肿瘤的诊断和判断预后有更加直接的作用。本文对尿液外泌体作为泌尿系统肿瘤早期诊断分子标志物的研究进展进行综述。

Exosomes are membranous vesicles secreted by a variety of cells,including tumor cells,with stable characters,which can reflect the physiological/pathological state of the source cells,indicating good sources of biomarkers for early diagnosis and prognosis of tumors.Urine exosomes are directly derived from the urinary system and play a more direct role in the diagnosis and prognosis of urinary system tumors.This paper reviews the recent advances in urinary exosomes as molecular markers for the early diagnosis of genitourinary tumors.