黄体酮联合加味寿胎丸治疗肾虚型早期先兆流产及对炎症因子影响

Effect of progesterone combined with modified shoutai pill for treating pregnant women with early threatened abortion because of kidney deficiency and its influence on inflammatory factors

目的:探究黄体酮联合加味寿胎丸治疗肾虚型早期先兆流产(TA)效果及对炎症因子影响。方法:回顾性分析2015年1月-2018年8月本院收治的TA患者临床资料98例,根据治疗方法的不同分为中西医组(54例)和西医组(44例),西医组给予黄体酮和绒毛膜促性腺激素(HCG)治疗,中西医组在西医组治疗基础上联合加味寿胎丸治疗。分析两组孕妇证候积分、早孕3项激素、炎症因子及妊娠结局。结果:治疗后两组各证候积分均低于治疗前,且中西医组证候积分阴道流血量(0.29±0.21分)、流血时间(0.20±0.15分)、流血色质(0.21±0.27分)、腰膝酸软(0.22±0.27分)、坠胀与下腹部疼痛(0.26±0.22分)均低于西医组(P<0.05);早孕3项指标雌二醇(1087.26±253.23pg/ml)、β-hCG(102633.32±6723.72 mIU/ml)、孕酮(80.93±8.24pg/ml)两组均高于治疗前,且中西医组高于西医组(P<0.05);中西医组IL-2(3.45±0.15 ng/ml)、IL-4(0.25±0.05 ng/ml)、INF-r(1.13±0.11ng/ml)水平改善程度优于西医组,保胎成功率(94.4%)高于西医组(84.1%),早产(0.0%)发生率低于对照组(13.5%)(均P<0.05)。结论:加味寿胎丸治疗TA,可改善临床症状,促进性激素分泌,纠正炎症因子病理性偏移,保胎效果较好。

Objective:To investigate the effect of progesterone combined with modified shoutai pill for treating pregnant women with early threatened abortion(TA)because of kidney deficiency,and to study its influence on inflammatory factors.Methods:The clinical data of 98 women with TA from January 2015 to August 2018 were retrospective analyzed.Among them,54 women in the study group were treated by progesterone and HCG combined with modified shoutai pill,and 44 women in the control group were treated by progesterone and HCG.The TCM syndrome scores,levels of sex hormones and inflammatory cytokines,and pregnancy outcomes of women were compared between the two groups.Results:After treatment,the TCM syndrome scores of all women in the two groups had significantly decreased,and the scores of vaginal bleeding(0.29±0.21 points),bleeding color(0.21±0.27points),lumbar and knee tenderness(0.22±0.27points),and swelling and lower abdominal pain scores(0.26±0.22 points),and bleeding time(0.20±0.15)of women in the study group were all signifficent lower than those of women in the control group(P<0.05).The levels of E2,β-hCG,and P of all women in the two groups had significantly increased after treatment,and the levels of E2(1087.26±253.23 pg/ml),β-hCG(102633.32±6723.72mIU/ml),and P(80.93±8.24pg/ml)of women in the study group were all signifficent higher than those of women in the control group(P<0.05).After treatment,the levels of IL-2(3.45±0.15ng/ml),IL-4(0.25±0.05ng/ml),and INF-r(1.13±0.11ng/ml)of women in the study group were signifficent better than those of women in the control group(P<0.05).The success rate of spuc treatment of women in the study group was 94.4%,which was significant higher than that(84.1%)of women in the control group(P<0.05),and the incidence of preterm labor of women in the study group was 0.0%,which was significant lower than that(13.5%)of women in the control group(P<0.05).Conclusion:Modified shoutai pill combined with progesterone and HCG for treating pregnant women with early threatened abortion can achieve good spuc treatment efficacy by alleviating clinical symptoms,promoting sex hormone level,and correcting the pathological shift of inflammatory factors of women.