女性泌尿生殖道沙眼衣原体感染与血清维生素D的关系

Relationship between Chlamydia trachomatis infection in genitourinary tract of women and serum vitamin D

目的探讨女性泌尿生殖道沙眼衣原体(Chlamydia trachomatis,Ct)感染与血清维生素D的关系。方法选择2016年1月-2017年12月在内蒙古民族大学附属医院进行治疗的女性Ct感染患者312例(病例组)及女性健康体检者350名(对照组)为研究对象,收集资料进行回顾性分析,探讨Ct感染与血清维生素D的关系。结果对照组的25-羟基维生素D[25-hydroxyvitamin D3,25-(OH)D]浓度为(54.11±16.69)nmol/L,高于病例组的(37.36±14.04)nmol/L,差异具有统计学意义(t=13.881,P<0.001)。病例组患者中,结局为"治愈"的患者的25-(OH)D浓度均高于结局为"未治愈"的患者,病例组各亚组的25-(OH)D浓度均低于对照组,差异均具有统计学意义[(54.11±16.69)nmol/L VS.(40.99±13.87)nmol/L VS.(32.00±12.58)nmol/L](P<0.05)。病例组患者经治疗后,25-(OH)D浓度出现增高,与治疗前相比,差异均具有统计学意义[(37.36±14.04)nmol/L VS.(49.64±14.81)nmol/L](t=-10.629,P<0.001)。结论维生素D水平不足可导致人群泌尿生殖道沙眼衣原体感染率增加,维生素D的水平也可作为泌尿生殖道沙眼衣原体感染治疗效果的指示物。

OBJECTIVE To investigate the relationship between Chlamydia trachomatis(Ct)infection in genitourinary tract of women and serum vitamin D.METHODS Totally 312 cases of female patients with Ct infection(the case group)and 350 female health checkups(the control group)treated at the Affiliated Hospital of Inner Mongolia University for Nationalities from Jan.2016 to Dec.2017 were included in the study.The data were retrospectively analyzed,and the relationship between Ct infection and serum vitamin D was discussed.RESULTS The concentration of 25-hydroxyvitamin D3[25-(OH)D]in the control group was(54.11±16.69)nmol/L,which was significantly higher than that in the case group(37.36±14.04)nmol/L(t=13.88,P<0.001).In the case group,patients with a"cure"outcome had a higher 25-(OH)D concentration than those with an"unhealed"outcome.The 25-(OH)D concentrations in each subgroup of the case group were lower than those in the control group.The data were significant[(54.11±16.69)nmol/L VS.(40.99±13.87)nmol/L VS.(32.00±12.58)nmol/L](P<0.05).In the case group,the 25-(OH)D concentration increased after treatment.Compared with the 25-(OH)D concentration before treatment,the data were significant[(37.36±14.04)nmol/L VS.(49.64±14.81)nmol/L](t=-10.629,P<0.001).CONCLUSION Insufficient vitamin D levels can lead to an increase in the infection rate of Chlamydia trachomatis in the genitourinary tract.Vitamin D levels can also be used as an indicator for the therapeutic effect of Ct infection in the genitourinary tract.