肝脏细胞分化和成熟的分子调控机制

Molecular Regulation Mechanism of Hepatic Lineage Differentiation and Maturation

肝脏是重要的代谢调控和药物解毒器官,执行体内多种生理功能。肝脏疾病已经越来越严重地影响着人体健康和生存质量。考虑到临床研究和转化医学的迫切需求,人们必须深入研究肝脏内各种细胞特别是肝实质细胞和胆管细胞的分化成熟过程及分子调控机制。该文概述了肝脏内起源于内胚层的肝实质细胞和胆管分化成熟的发育过程,总结了调控此过程的信号通路和转录因子,并简要介绍了最新技术对于肝脏发育研究的推动作用。这些结果对于人们在体外高效地诱导得到或建立更成熟、结构功能更完善的肝脏样细胞或肝脏类器官以及肝脏疾病的研究与治疗有重要意义。

The liver is an important organ for metabolic regulation and drug detoxification that performs a variety of physiological functions in the body.Liver diseases have increasingly affected human health and quality of life.Considering urgent needs for clinical research and translational medicine,we must thoroughly define the differentiation and maturation processes and molecular regulatory mechanisms of liver cells,especially hepatocytes and cholangiocytes.This article outlines the differentiation and maturation processes of endoderm derived hepatic lineages,summarizes the signaling pathways and transcription factors involved in these developmental processes,and briefly introduces the promotion of advanced technologies for liver development research.These achievements guide us to efficiently induce or establish more mature liver-like cells or organoids in vitro for liver disease-related research and treatment.