葡萄糖醛酸功能化双介孔硅对胆红素的高效吸附研究

Bimodal mesoporous silica functionalized with glucuronic acid as a highly effective adsorbent for bilirubin removal

胆红素是由衰老及异常红细胞被吞噬、血红蛋白分解代谢产生的一种生物活性物质。采用具有小孔径和较大孔径两种介孔孔道的双介孔硅作为基底材料,并用葡萄糖醛酸对双介孔硅进行功能化,以实现对胆红素的选择性吸附。研究了吸附时间、温度、初始浓度、血清蛋白、离子强度对胆红素吸附的影响。实验结果表明,葡萄糖醛酸化双介孔硅对胆红素的吸附快速、高效,吸附平衡为15 min,最大吸附量为(246.78.3)mg/g,血清蛋白的存在对胆红素吸附的影响不大。胆红素吸附符合二级吸附动力学模型和Langmuir等温吸附模型。

Bilirubin is a bioactive substance that is produced by the aging and abnormal red blood cells phagocytosis and hemoglobin catabolism.In order to accelerate mass transfer,bimodal mesoporous silica with small and larger mesopores was adopted as bilirubin adsorbent substrate.Glucuronic acid was grafted on bimodal mesoporous silica to improve selectivity towards bilirubin adsorption.Effect of equilibrium time,temperature,initial concentrations of bilirubin,human serum bovine and ionic strength on bilirubin adsorption was thoroughly investigated.Experimental results revealed that glucuronized bimodal mesoporous silica was a rapid and highly effective adsorbent for bilirubin removal.The equilibrium time was 15 min and the maximum adsorption capacity for bilirubin was(246.78.3)mg/g.The adsorbent showed good selectivity of bilirubin against serum albumin.The adsorption of bilirubin on mesoporous silica could be described by second-order kinetic equation and the Langmuir isotherm equation.