超重人群结肠镜检查肠道准备中洗肠液使用剂量研究

Dosage Study of Intestinal Lavage Solution in Bowel Preparation for Colonoscopy in Overweight Population

目的探索在超重人群中增加洗肠液使用剂量是否可提高肠道准备清洁度及不良反应事件的发生情况。方法纳入2016年9月至2018年3月行结肠镜检查的超重患者(体质指数>24.0kg/m^2)共109例,随机数字表法分组。其中对照组69例患者服用标准剂量的洗肠液,试验组(加量洗肠液组)40例患者服用加量剂量的洗肠液进行肠道准备。采用波士顿肠道准备评分标准评价两组肠道准备情况并比较两组不良反应发生情况。结果试验组与对照组相比无论在左半结肠、横结肠、右半结肠还是总体肠道清洁度的波士顿评分中,两组差异均无统计学意义(P>0.05)。在不良反应发生情况中,试验组与对照组在恶心、呕吐、腹胀、腹痛、头晕、心悸、电解质紊乱的发生上差异均无统计学意义(P>0.05)。结论在进行结肠镜检查的超重人群中,暂不建议为提高肠道准备合格率而增加洗肠液使用剂量。

Objective To explore whether increasing the dosage of intestinal lavage solution in overweight population can improve the cleanliness of bowel preparation and explore the occurrence of adverse events.Methods A total of 109 overweight patients(body mass index> 24.0 kg.m-2) who underwent colonoscopy from September 2016 to March 2018 were enrolled,who were divided into two groups according to random number table method.Among them,69 patients in the control group received standard dose of intestinal lavage solution;40 patients in the study group(increased dose of intestinal lavage solution) received an increased dose of intestinal lavage solution for bowel preparation.Situation of bowel preparation evaluated according to Boston Bowel Preparation Scoring Criteria and the occurrence of adverse reactions between the two groups were compared.Results The Boston scores of left colon,transverse colon,right colon and overall bowel cleanliness between the two groups showed no statistically significant differences.For the occurrence of adverse reactions,there was no significant difference in the incidence of nausea,vomiting,abdominal distension,abdominal pain,dizziness,palpitations and electrolyte imbalance between the study group and the control group(P>0.05).Conclusion It is not recommended to increase the dosage of intestinal lavage solution to improve success rate of bowel preparation in overweight population who underwent colonoscopy.