补充维生素D对慢性阻塞性肺疾病患者的影响

Effects of Vitamin D Supplementation on Patients with Chronic Obstructive Pulmonary Disease

为了探讨维生素D对重度吸烟伴维生素D缺乏的慢性阻塞性肺疾病(COPD)患者肺功能及生活质量的影响,研究收集60例重度吸烟且维生素D缺乏(血清25羟维生素D≤20ng/mL)的COPD稳定期男性患者,随机分为2组。对照组(30例)给予常规治疗,实验组(30例)在常规治疗基础上给予维生素D3400mg,口服,bid×6月,均随访6个月。开始治疗前2组患者CAT问卷评分、FEV1/FVC(%)、FEV1(%)无显著差异(P>0.05)。治疗6个月后,与对照组比较,实验组FEV1(%)、FEV1/FVC(%)明显改善(均有P<0.05),CAT问卷评分明显降低(P<0.05),随访6个月实验组急性加重次数明显少于对照组(P<0.05)。结果表明,补充维生素D可以改善重度吸烟伴维生素D缺乏COPD男性患者的肺功能及生活质量,减少急性加重次数,值得临床进一步研究推广。

In order to investigate the effect of vitamin D on lung function and quality of life in chronic obstructive pulmonary disease(COPD)patients with severe smoking and vitamin D deficiency,60 male COPD patients in stable stage with severe smoking and vitamin D deficiency(serum 25-hydroxyvitamin D≤20ng/mL)were randomly divided into two groups.The control group(30cases)was given routine treatment,while the experimental group(30cases)was given vitamin D3400mg,po,bid x 6 months on the basis of routine treatment.All patients were followed up for 6 months.There was no significant difference in the scores of CAT questionnaire,FEV1/FVC(%)and FEV1(%)between the two groups before treatment(P>0.05).After 6 months of treatment,compared with the control group,the FEV1(%)and FEV1/FVC(%)in the experimental group were significantly improved(all P<0.05),the score of CAT questionnaire was significantly reduced(P<0.05),and the number of acute exacerbations in the experimental group was significantly smaller than that in the control group after 6 months of follow-up(P<0.05).The results showed that vitamin D supplementation can improve the lung function and quality of life in male COPD patients with severe smoking and vitamin D deficiency,and reduce the number of acute exacerbations,which is worthy of further clinical research and promotion.