病原菌调节宿主细胞泛素化途径的研究进展

Modulation of Host Ubiquitination Pathways by Pathogenic Bacterial Effector Proteins

泛素化是真核生物特有的蛋白质翻译后修饰,广泛地参与宿主细胞各种信号通路和生理过程.病原菌常通过分泌毒性效应蛋白,对泛素和泛素结合酶进行独特的共价修饰,或者利用泛素连接酶和去泛素化酶的酶学活性,调节宿主泛素化过程,从而干扰宿主细胞的信号转导,促进细菌的感染和生存.本文概述了病原菌效应蛋白调节宿主泛素化途径的主要研究进展和最新发现.

Ubiquitination is a prevalent posttranslational modification in eukaryotic cells.Ubiquitination almost regulates all eukaryotic signaling pathways,thereby playing essential roles in eukaryotic cellular processes including immune responses.Bacterial pathogens inject a series of virulence proteins,named effectors,via special protein secretion systems,such as typeⅢand typeⅣsecretion systems,into the host cells to modulate host signaling pathways.Many effectors harbor unique enzymatic activities to modify ubiquitin or the ubiquitinconjugating enzyme Ubc13,or have E3 ubiquitin ligase or deubiquitinase activities.This review summarizes the progresses and the newest discoveries on mechanisms of host ubiquitination modulation by bacterial effector proteins.