摘要
阿尔兹海默病(AD)是一种常见的神经退行性疾病,临床表现以渐进性认知和记忆功能减退等为特征,在疾病晚期可严重影响患者的身心健康和生活质量。AD的早期诊断仍是全球面临的重大难题之一。β淀粉样肽(Aβ)沉积形成的Aβ斑块和Tau蛋白过度磷酸化形成的神经原纤维缠结为AD的标志性病理改变,Aβ和Tau蛋白的检测对实现AD早期诊断至关重要。近年来,纳米技术发展迅速,基于纳米技术的Aβ或Tau蛋白靶向检测为AD的早期诊断提供了可能。笔者对基于纳米技术的AD诊断研究进行综述。
Alzheimer's disease(AD)is a common neurodegenerative disorder,which is clinically characterized by progressive cognitive deficit and memory impairment.It seriously affects mental health,physical activity,and quality of life of patients in the late stage.However,early diagnosis of AD remains one of the greatest challenges worldwide.Extracellular amyloid-β(Aβ)plaques composed of Aβand intraneuronal neurofibrillary tangles consisting of hyperphosphorylated Tau proteins are considered as the key pathological hallmarks of AD.Detection of Aβand Tau protein is considered critical for the early diagnosis of AD.In recent decades,nanotechnology has developed rapidly,and nanotechnology-based Aβ-or Tau-targeted detection has provided the possibility for the early diagnosis of AD.The present review focuses on the research of nanotechnology in the diagnosis of AD.
作者
张凯
施可欣
金晨涛
田梅
张明荣
张宏
Zhang Kai;Shi Kexin;Jin Chentao;Tian Mei;Zhang Mingrong;Zhang Hong(Department of Nuclear Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Zhejiang University Medical PET Center,Hangzhou 310009,China;National Institutes for Quantum and Radiological Science and Technology,Chiba 263-8555,Japan;Shanxi Medical University,Taiyuan 030001,China;Key Labratory for Biomedical Engineering of Ministry of Education,Zhejiang University,Hangzhou 310009,China;The College of Biomedical Engineering and Instrument Science of Zhejiang University,Hangzhou 310009,China)
出处
《国际放射医学核医学杂志》
2019年第6期496-502,共7页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家杰出青年科学基金项目(81425015、81725009)。
