神经元特异性烯醇化酶对颅脑损伤患者神经功能预后的评估价值

Values of neuron-specific enolase in patients with craniocerebral injury in prognostic assessment of neurological function

目的探讨不同原因导致的颅脑损伤患者的神经元特异性烯醇化酶(NSE)在血清中表达水平变化与患者病情严重程度及预后关系.方法回顾性分析2016年4月至2016年12月江苏大学附属武进医院重症医学科收治38例患者,其中男性28例,女性10例;年龄25~87岁,平均(53.9±13.3)岁.入院时根据GCS评分分为3组:轻中型组(GCS 9~15分)10例,重型组(GCS 6~8分)14例,特重型组(GCS 3~5分)14例.对各组患者分别进行APACHEⅡ评分并检测血清NSE水平.结果所有患者血清NSE水平升高,特重型组高于中重型组和轻型组(P<0.05),且NSE水平越高,APACHEⅡ评分越高,患者病死率越高.结论神经元特异性烯醇化酶表达变化可以作为辅助评价颅脑损伤程度的实验室指标,且与患者预后呈负相关.

Objective To investigate the relationship between the expression of neuron specific enolase(NSE) in serum and the severity and prognosis of patients with brain injury caused by different causes. Methods A retrospective analysis of 38 patients admitted to our intensive care unit from June 2018 to June 2019 was performed,including 28 males and 10 females, aged 25-87 years with an average age of(53.9 ± 13.3) years.The patients who met the admission criteria were GCS scores. The patients were divided into three groups according to the GCS score:mild and intermediate group(group A), severe group(group B) and very severe group(group C). There were 10 cases in group A(GCS 9-15 points), 14 cases in group B(GCS 6-8 points), and 14 cases in group C(GCS 3 to 5 points). The above grouped patients were scored APACHE II respectively. Serum NSE levels were detected. Results The serum NSE levels of all patients with craniocerebral injury were higher than those of the moderately severe group and the mild group(P<0.05). The higher the NSE level, the higher the APACHE II score and the higher the mortality rate. Conclusion The expression of neuron-specific enolase can be used as a laboratory index to evaluate the degree of craniocerebral injury and is negatively correlated with the prognosis of patients.