纽约食管鳞状细胞癌1的研究进展

Progress in research of New York esophageal squamous cell carcinoma 1

纽约食管鳞状细胞癌1(New York esophageal squamous cell carcinoma 1,NY-ESO-1)是一种癌-睾丸抗原。其表达于多种肿瘤,但在正常组织中极少表达,且具有可同时诱导体液和细胞免疫应答的强免疫原性,因此被认为是一种肿瘤免疫治疗的理想抗原。此文概述了对NY-ESO-1与肿瘤的相关研究以及基于NY-ESO-1的免疫治疗的研究进展。

New York esophageal squamous cell carcinoma 1(NY-ESO-1)is a member of cancer-testis antigens.NY-ESO-1’s characteristic expression in multiple types of human cancers but rare presence in normal tissues,together with its ability to simulataneously elicit humoral and cellular immune responses,have rendered it a good candidate target for cancer immunotherapy.This paper reviews the studies of NY-ESO-1 association with cancers and the research progresses of NY-ESO-1 targeted immunotherapeutic strategies.