小剂量异丙酚复合麻醉对冠心病高危因素人群心率变异性的影响研究

Effects of low dose propofol combined anesthesia on heart rate variability in patients with high risk factors of coronary heart disease

目的分析小剂量异丙酚复合麻醉对冠心病高危因素人群心率变异性的影响。方法选取2017年1月至2019年1月收治的110例冠心病高危因素手术人群,随机分为观察组和对照组,每组55例。对照组以依托咪酯为核心药物进行复合麻醉,观察组以异丙酚为核心药物进行复合麻醉,对比2组血流动力指标变化、心率变异性参数、风险发生率和麻醉有效率。结果2组麻醉有效率以及麻醉前血流动力指标对比,差异无统计学意义(P>0.05)。麻醉后观察组风险发生率低,血流动力指标和心率变异性参数更理想,与对照组相比,差异有统计学意义(P<0.05)。结论小剂量异丙酚复合麻醉对冠心病高危因素病人心率变异性的影响偏小,可维持麻醉效果并保持患者血流动力态势稳定。

Objective To investigate the Effects of low dose propofol combined anesthesia on heart rate variability in patients with high risk factors of coronary heart disease.Methods A total of 110 patients with high-risk factors of coronary heart disease who were treated in our hospital from January 2017 to June 2019 were randomly divided into observation group and control group,with 55 cases in each group.The patients in control group received compound anesthesia with etomidic vinegar as the core drug,however,the patients in observation group received compound anesthesia with propofol as the core drug.The changes of hemodynamic indexes,HRV parameters,risk incidence and anesthesia efficiency were observed and compared between the two groups.Results There were no significant differences in anesthesia efficiency and hemodynamic parameters before anesthesia between the two groups(P>0.05).After anesthesia,the risk rate in observation group was lower,and hemodynamic parameters and heart rate variability parameters were superior to those in control group(P<0.05).Conclusion The low dose propofol combined anesthesia has little effect on heart rate variability in patients with high risk factors of coronary heart disease,which can maintain anesthetic effects and keep stable hemodynamic situation.