C反应蛋白介导的牙周炎与全身系统性疾病相关机制研究进展

Research progress on the mechanism of C-reactive protein mediated periodontitis and systemic diseases

大量研究证实牙周炎与全身多系统疾病有着密切的关系。牙周组织的局部炎症可能会引起全身炎症反应。C反应蛋白(C-reactive protein,CRP)作为一种炎性因子,被广泛用于监测各种炎症状态,不仅和牙周炎有着高度的相关性,同时与全身系统性疾病之间存在密切的联系。本文从牙周炎与全身系统性疾病流行病学的关系、CRP在两者之间联系的机制等方面作一综述。文献复习表明,牙周炎与心血管疾病、糖尿病、早产及低出生体重儿、慢性肾病及类风湿关节炎等全身疾病之间有着密切联系。牙周炎作为慢性炎症性疾病可以使血清CRP水平增高,从而增加心血管疾病的危险性,影响糖尿病患者的血糖控制,可能与早产风险增加和低出生体重儿有关,可能影响慢性肾病发展,可作为类风湿性关节炎活动期的敏感指标之一。通过牙周治疗可以降低血清CRP水平从而有助于系统性疾病的治疗。CRP水平能够作为牙周炎和全身系统性疾病的预防、诊断和治疗的监测指标。

A large number of studies have confirmed that periodontitis is closely related to systemic multisystem diseases. Local inflammation of periodontal tissue may cause systemic inflammation. As an inflammatory factor, C-reactive protein(CRP) is widely used to monitor various inflammatory states. CRP is not only highly related to periodontitis but also closely related to systemic diseases. This article reviews the relationship between periodontitis and systemic disease epidemiology as well as the mechanism of CRP in the relationship between them. The literature review shows that periodontitis is closely related to cardiovascular diseases, diabetes, premature and low-birth-weight infants, chronic kidney disease, rheumatoid arthritis and other systemic diseases. Periodontitis, as a chronic inflammatory disease, can increase the level of serum CRP, thus increasing the risk of cardiovascular disease and affecting blood glucose control in diabetic patients, which may be related to the increased risk of premature delivery and low-birth-weight infants, may affect the development of chronic kidney disease, and may be used as one of the sensitive indicators of rheumatoid arthritis in the active stage. Through periodontal treatment, serum CRP levels can be reduced, which is helpful for the treatment of systemic diseases. CRP levels can be used as indicator for prevention, diagnosis and treatment of periodontitis and systemic diseases.