综合康复疗法联合神经节苷脂对痉挛型脑瘫患儿粗大运动功能及生活质量的影响分析

Effect analysis of comprehensive rehabilitation therapy combined with ganglioside on gross motor function and quality of life in children with spastic cerebral palsy

目的探讨综合康复疗法联合神经节苷脂对痉挛型脑瘫患儿粗大运动功能与生活质量的影响。方法选择某院2014年1月至2018年6月收治的痉挛型脑瘫患儿作为研究对象,共计80例,采用随机数表法将其分为40例观察组和40例对照组,对照组患儿采用综合康复疗法,观察组患儿在此基础上采用神经节苷脂进行治疗,两组患儿持续治疗6周,比较两组患儿治疗效果,以及治疗前后D区(站立)和E区(跑、跳及步行)的粗大运动功能评分和治疗前后PedsQLTM生活质量评分。结果治疗后观察组患儿治疗显效28例、有效11例、无效1例,临床治疗总有效率为97.5%,对照组患儿显效13例、有效18例、无效9例,总有效率仅为77.5%,低于观察组,差异有统计学意义(P<0.05)。在GMFM评分方面,观察组患儿治疗前D区、E区评分分别为(26.8±8.2)分和(33.3±12.1)分,与对照组患儿的(26.5±7.3)分及(33.4±13.0)分对比,差异无统计学意义(P>0.05),治疗后观察组患儿D区、E区评分分别为(35.3±11.9)分和(44.5±11.2)分,比对照组患儿评分上升幅度更大,差异有统计学意义(P<0.05)。观察组与对照组患儿治疗前生活质量评分分别是(37.2±3.5)分和(37.4±4.0)分,差异无统计学意义(P>0.05),治疗后分别为(68.5±8.1)分和(60.1±7.8)分,均有显著的提升,差异有统计学意义(P<0.05),而观察组患儿的生活质量提升幅度明显更高,差异有统计学意义(P<0.05)。结论为痉挛型脑瘫患儿积极提供综合康复疗法联合神经节苷脂进行治疗,有助于提升患儿的临床治疗效果,同时提高患儿粗大运动功能,改善生活质量。

Objective To explore the effects of comprehensive rehabilitation therapy combined with ganglioside on gross motor function and quality of life in children with spastic cerebral palsy.Me thods 80 children with spastic cerebral palsy admitted to our hospital from January 2014 to June 2018 were selected as the research subjects.They were divided into observation group and control group by random number table method,with 40 cases in each group.The control group was treated with comprehensive rehabilitation therapy,and the observation group was treated with additional ganglioside on the basis for the control group.After 6 weeks of continuous treatment,the therapeutic effect,gross motor function score in D zone(standing)and E zone(running,jumping and walking)and PedsQLTM quality of life score before and after treatment were compared between the two groups.Re s ults After treatment,28 cases were markedly effective,11 cases were effective and 1 case was ineffective in the observation group.The total clinical effective rate was 97.5%.In the control group,13 cases were markedly effective,18 cases were effective and 9 cases were ineffective.The total clinical effective rate was only 77.5%.It was lower than that in the observation group,with statistically significant differences(P<0.05).In terms of GMFM score,the scores of D and E zones in the observation group before treatment were(26.8±8.2)and(33.3±12.1)respectively.Compared with the scores of(26.5±7.3)and(33.4±13.0)in the control group,there were not statistically significant differences(P>0.05).After treatment,the scores of D and E zones in the observation group were(35.3±11.9)and(44.5±11.2),with higher increase range than that in the control group,and with statistically significant differences(P<0.05).The scores of quality of life in the observation group and the control group before treatment were(37.2±3.5)and(37.4±4.0)respectively,without statistically significant differences(P>0.05).After treatment,they were(68.5±8.1)and(60.1±7.8)respectively,with significant improvement and statistically significant differences(P<0.05).While the improvement of quality of life in the observation group was remarkably higher,with statistically significant differences(P<0.05).Conclus ion Comprehensive rehabilitation therapy combined with ganglioside is helpful to improve the clinical therapeutic effect of children with spastic cerebral palsy.It can also improve the gross motor function and quality of life for the children sufferers.