p22phox基因C242T多态性与脑梗死关系的Meta分析

Meta-analysis of the relationship between gene C242T polymorphism and cerebral infarction

【目的】评价C242T基因多态性与脑梗死的关系。【方法】对国内外公开发表的关于脑梗死C242T基因多态性的病例对照研究用Review Manager 5.3进行Meta分析。【结果】共纳入10个病例对照研究,包括脑梗死病例2548例,对照组2753例。Meta分析结果表明,在对等位基因模型(OR=1.53,95%CI:1.09~2.13,I^2=75%,P<0.001)和显性模型(OR=1.59,95%CI:1.11~2.27,I^2=74%,P<0.001)分析中,显示这两种模型差异有统计学意义;在加性模型(OR=1.09,95%CI:0.67~1.77,I^2=0%,P=0.60)和隐性模型(OR=1.06,95%CI:0.65~1.73,I^2=0%,P=0.64)分析中,显示这两种模型差异无统计学意义。【结论】p22^phox基因C242T多态性与脑梗死相关,携带T等位基因的个体发生脑梗死的风险较高。

【Objective】To evaluate the relaitonship between gene C242T polymorphism and cerebral infarction.【Methods】Published case-control studies on the C242T gene polymorphism of cerebral infarction were performed by Review Manager 5.3 for a Metaanalysis.【Results】A total of 10 case-control studies were included,including 2548 cases with cerebral infarction and 2753 cases in the control group.Meta-analysis results showed that the allelic model(OR=1.53,95%CI:1.09-2.13,I2=75%,P<0.001)and dominant model(OR=1.59,95%CI:1.11-2.27,I2=74%,P<0.001)were significantly associated with the risk of cerebral infarction.The additive model(OR=1.09,95%CI:0.67-1.77,I2=0%,P=0.60)and recessive model(OR=1.06,95%CI:0.65-1.73,I^2=0%,P=0.64)showed no correlation with the risk of cerebral infarction.【Conclusion】The p22^phox gene C242T polymorphism is associated with cerebral infarction.Individuals carrying the T allele may have a higher risk of cerebral infarction.