无创正压通气联合甲基强的松龙对重症支气管哮喘伴呼吸衰竭患者血气指标及并发症的影响

Effect of Noninvasive Positive Pressure Ventilation Combined with Methylprednisolone on Blood gas Indexes and Complications in Patients with Severe Bronchial Asthma with Respiratory Failure

目的研究无创正压通气联合甲基强的松龙对重症支气管哮喘伴呼吸衰竭患者血气指标及并发症的影响。方法将2014年2月-2019年2月郑州市第三人民医院收治的重症支气管哮喘伴呼吸衰竭患者60例依据随机数表法分为对照组和观察组,每组30例。对照组给予无创正压通气治疗,观察组在对照组基础上联合甲基强的松龙治疗。对比分析两组患者的临床疗效及并发症发生情况。研究两组患者的血气指标变化。结果治疗1周后,观察组PaCO2水平及并发症总发生率低于对照组,Sp02、PaO2水平及治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。结论使用无创正压通气联合甲基强的松龙治疗重症支气管哮喘伴呼吸衰竭,能够显著提升治疗效果,大幅改善患者血气指标,降低并发症发生率。

Objective To study the effects of non-invasive positive pressure ventilation combined with methylprednisolone on the blood gas index and complications of severe bronchial asthma with respiratory failure.Methods 60 patients with severe bronchial asthma with respiratory failure from February,2014 to February,2019 were divided into control group and observation group according to the random number table method.The control group was treated with non-invasive positive pressure ventilation,and the observation group was treated with methylprednisolone on the basis of the control group.The clinical efficacy and complications of the two groups were compared and analyzed.The blood gas index of the two groups was studied.Results After 1 week of treatment,the total incidence of PaCO2 and complications of observation group were lower than those of the control group,and the level of Sp O2 and Pa O2 and the total effective rate of the treatment were higher than those of the control group(P<0.05).Conclusion The use of non-invasive positive pressure ventilation combined with methylprednisolone in the treatment of severe bronchial asthma with respiratory failure can significantly improve the treatment effect,greatly improve the blood gas index of patients and reduce the incidence of complications.