摘要
A promoter-free Friedel-Crafts trifluoromethylthiolation of electron-rich arenes and heteroarenes with N-trifluoromethylthiosaccharin 5 using 2,2,2-trifluoroethanol(TFE) as the solvent was described.The reactions were conducted at 40℃and a variety of common functional groups were compatible.
A promoter-free Friedel-Crafts trifluoromethylthiolation of electron-rich arenes and heteroarenes with N-trifluoromethylthiosaccharin 5 using 2,2,2-trifluoroethanol(TFE) as the solvent was described.The reactions were conducted at 40℃and a variety of common functional groups were compatible.
基金
the financial support from the National Natural Science Foundation of China (Nos.21625206, 21632009,21572258,21421002)
the Natural Science Foundation of Shanghai (No.17ZR1447100)
the Science and Technology Commission of Shanghai Municipality (No.14DZ2261000)
