DNA免疫吸附治疗重度活动性系统性红斑狼疮的疗效观察

The curative effect observation of DNA immunosorbent therapy in the treatment of severe active systemic lupus erythematosus

目的:观察DNA免疫吸附治疗重度活动性系统性红斑狼疮(SLE)的临床疗效及安全性。方法:2017年1月-2018年12月收治重症SLE患者24例,分为两组。常规治疗组采用常规治疗,DNA吸附组在常规治疗的基础上采用免疫吸附治疗。比较两组治疗效果。结果:DNA吸附组临床症状改善明显优于常规治疗组,差异有统计学意义(P<0.05)。两组治疗后ANA、ds-DNA抗体、免疫球蛋白指标明显下降,DNA吸附组下降效果更显著,差异有统计学意义(P<0.05)。两组补体C3指标均升高,差异无统计学意义(P>0.05)。两组对肝肾功能、血常规等指标均无明显影响。结论:DNA免疫吸附治疗重度活动性SLE有明显的临床疗效,是一种新的治疗手段。

Objective:To observe the clinical efficacy and safety of DNA immunoadsorption in the treatment of severe active systemic lupus erythematosus(SLE).Methods:24 patients with severe SLE were selected from January 2017 to December 2018,they were divided into the two groups.Routine treatment was used in the routine treatment group,the DNA adsorption group was treated by immunoadsorption on the basis of routine treatment.The therapeutic effects of the two groups were compared.Results:The clinical effect of the DNA adsorption group was better than that of the conventional treatment group,after treatment,the ANA ds-DNA antibody and immunoglobulin decreased significantly in both groups,the effect of the DNA adsorption group was more significant,the differences were statistically significant(P<0.05).The C3 index of complement increased in both groups,there was no significant difference(P<0.05).The two groups had no significant effect on liver and kidney function and blood routine test.Conclusion:DNA immunoadsorption has obvious clinical effect on severe active SLE,it is a new treatment.