利培酮与喹硫平治疗100例老年脑血管病所致精神障碍患者疗效观察

Effect of risperidone and quetiapine in the treatment of 100 elderly patients with mental disorders caused by cerebrovascular disease

目的:探讨利培酮与喹硫平治疗老年脑血管病所致精神障碍患者的临床疗效。方法:2017年10月-2019年9月收治老年脑血管病所致精神障碍患者100例,随机分为两组,各50例,分别采用利培酮和喹硫平治疗。比较两组临床疗效、日常生活质量(ADL)和症状量表(PANSS)评分。结果:两组临床总有效率、治疗后PANSS评分比较,差异无统计学意义(P>0.05)。喹硫平组治疗后ADL评分优于利培酮组,不良反应率明显低于利培酮组,差异有统计学意义(P<0.05)。结论:利培酮与喹硫平均为治疗老年脑血管病所致精神障碍患者的有效药物,但喹硫平引起的不良反应较少,可明显改善患者日常生活质量。

Objective:To explore the effect of risperidone and quetiapine in the treatment of elderly patients with mental disorders caused by cerebrovascular disease.Methods:From October 2017 to September 2019,100 elderly patients with mental disorders caused by cerebrovascular disease were selected,and they were randomly divided into two groups of 50 cases in each,two groups were treated with risperidone and quetiapine respectively.We compared the clinical efficacy,ADL and PANSS of the two groups.Results:There was no significant difference in total clinical response rate and PANSS score after treatment between the two groups(P>0.05).In the quetiapine group,the ADL score after treatment was better than that in the risperidone group,and the adverse reaction rate was significantly lower than that in the risperidone group,the difference was statistically significant(P<0.05).Conclusion:Risperidone and quetiazide are effective drugs in the treatment of mental disorders caused by cerebrovascular diseases in the elderly,however,quetiapine causes fewer adverse reactions,which can significantly improve the quality of daily life of patients.