不同剂量米非司酮治疗子宫肌瘤效果比较

Comparison of the effects of different doses of mifepristone in the treatment of hysteromyoma

目的:探讨不同剂量米非司酮用于子宫肌瘤的治疗价值。方法:2017年3月-2018年3月收治子宫肌瘤患者100例,随机分为两组。对照组以10 mg作为单次剂量,观察组以12.5 mg作为单次剂量。比较两组治疗效果。结果:观察组治疗总有效率、不良反应发生率高于对照组,孕酮、雌二醇、促黄体生成素、血清促卵泡素含量均低于对照组,差异均有统计学意义(P<0.05)。结论:以单次剂量为12.5 mg的米非司酮治疗子宫肌瘤疗效显著,但不良反应较多。

Objective:To explore the therapeutic value of different doses of mifepristone in the treatment of hysteromyoma.Methods:100 patients with hysteromyoma were selected from March 2017 to March 2018,they were randomly divided into the two groups.The control group took 10 mg as a single dose,in the observation group,12.5 mg was used as a single dose.The therapeutic effects of the two groups were compared.Results:The total effective rate of the observation group was higher than the control group,the contents of progesterone,estradiol,luteinizing hormone and serum follicle stimulating hormone in the observation group were lower than those in the control group,the incidence of adverse reactions in the observation group was higher than the control group,the differences were statistically significant(P<0.05).Conclusion:A single dose of 12.5 mg of mifepristone is effective in the treatment of uterine leiomyoma,but there are many adverse reactions.