欣母沛不同给药时机对瘢痕子宫患者出血量影响的研究

Study on the effect of different administration time on bleeding volume of hemabate in patients with scar uterus

目的探讨不同给药时机应用欣母沛对瘢痕子宫患者的出血量的影响。方法回顾性选取2014年3月-2016年11月于妇产科诊治的瘢痕子宫产妇97例为研究对象,根据欣母沛用药时机分为研究组(分娩后立即注射)48例和对照组(分娩后出血量较多时注射)49例。观察两组患者的出血情况、欣母沛使用量、不良反应及治疗效果。结果研究组患者术中出血量(650.34±174.36)ml、产后2 h(142.67±32.58)ml、产后24 h(159.45±36.27)ml均低于对照组患者(均P<0.05);研究组患者的产后出血发生率37.50%明显低于对照组患者的59.18%,欣母沛使用量为(10.2±1.3)支明显低于对照组(18.4±1.8)支(均P<0.05);研究组患者的不良反应发生率为4.17%,仅有2例发生血压升高,对照组患者的不良反应发生率为14.29%,其中血压升高3例,头痛2例,恶心2例,呕吐2例,(均P<0.05);研究组患者的治疗总有效率为100%明显高于对照组的95.92%(P<0.05)。结论瘢痕子宫患者在分娩后易发生大出血、情况危急,在胎儿分娩后应立即给予注射欣母沛,可明显降低产后出血率,确保母婴生命安全。

Objective To analyze the effectof different administration time on bleeding volume of hemabate in patients with scar uterus.Methods 97 cases of scar uterine maternal diagnosed in the department of obstetrics and gynecology of our hospital from March 2014 to November 2010 were retrospectively chosen as the study object.The patients were divided into study group(injected immediately after delivery group)48 cases and control group(injected with more bleeding after delivery group)49 cases according to the application opportunity of hemabate.The bleeding situation,the amount of hemabate,adverse reactions and treatment effect of the two groups were compared.Results The intraoperative bleeding volume(650.34±174.36)ml,2 h(142.67±32.58)ml postpartum,and postoperative 24 h(159.45±36.27)ml in the study group were lower than those in the control group(all P<0.05).The incidence of postpartum hemorrhage in the study group of 37.50%was significantly lower than that in the control group of 59.18%,and the amount of hemabate(10.2±1.3)injection was significantly lower than that of the control group(18.4±1.8)injection(all P<0.05).The incidence of adverse reactions in the study group was 4.17%,only 2 cases were with the increasing of blood pressure.The incidence of adverse reactions in the control group was 14.29%,including blood pressure in 3 cases,2 cases of headache,2 cases of nausea,vomiting 2 cases(all P<0.05).The total effective rate of treatment in the study group 100%was significantly higher than that in the control group 95.92%(P<0.05).Conclusion Scar uterine patients in the postpartum are prone to bleeding,the situation is critical.Immediate hemabate should be given in the fetal delivery,can significantly reduce the rate of postpartum hemorrhage,and ensure the safety of mother and child life.