血清高敏C-反应蛋白、肿瘤坏死因子-α联合肺功能检测在诊断慢性阻塞性肺疾病中的应用价值分析

Analysis of the application value of serum hs-CRP and TNF-αcombined with pulmonary function test in the diagnosis of chronic obstructive pulmonary disease

目的研究血清高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)联合肺功能检测在诊断慢性阻塞性肺疾病(COPD)中的应用价值。方法将2017年1月-2018年10月于本院接受诊治的129例慢性阻塞性肺疾病患者作为观察对象,其中稳定期60例(稳定期组)、急性加重期69例(AECOPD组);另选取60例同期于本院接受健康体检者作为健康对照组。对3组人员的血清hs-CRP、TNF-α表达水平及肺功能进行检测,分析血清hs-CRP、TNF-α表达水平和肺功能的相关性。结果AECOPD组、稳定期组患者的血清hs-CRP、TNF-α表达水平高于健康对照组,AECOPD组高于稳定期组(P<0.05);随着AECOPD组患者的肺功能分级增高,血清hs-CRP、TNF-α表达水平不断增加(P<0.05);AECOPD组、稳定期组患者的肺功能指标FEV1、FEV1/FVC值均低于健康对照组,AECOPD组低于稳定期组(P<0.05);COPD患者的血清hs-CRP、TNF-α表达水平与肺功能指标FEV1、FEV1/FVC值均显示为负相关(r值分别为-0.326、-0.635和-0.306、-0.511,P<0.05)。结论联合检测血清hs-CRP、TNF-α联合肺功能可以帮助临床诊断慢性阻塞性肺疾病,判定慢性阻塞性肺疾病的严重程度,进而为临床早期治疗提供指导。

Objective To study the value of serum high-sensitivity C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)combined with pulmonary function test in the diagnosis of chronic obstructive pulmonary disease(COPD).Methods A total of 129 patients with chronic obstructive pulmonary disease who were treated in our hospital from January 2017 to October 2018 were enrolled.Among them,60 cases were stable(stable period group)and 69 cases were acute exacerbation period(AECOPD group);in addition,60 cases of normal people who received a physical examination at the same time were selected as the control group.The serum hs-CRP,TNF-αlevels and lung function were measured in three groups,and the correlation between serum hs-CRP,TNF-αexpression and lung function was analyzed.Results The serum levels of hs-CRP and TNF-αin the AECOPD group and the stable group were higher than those in the healthy control group,and the AECOPD group was higher than the stable group(P<0.05).With the increasing grade of lung function in patients with AECOPD,the levels of hs-CRP and TNF-αin serum were also increasing(P<0.05).The FIV1 and FEV1/FVC values of lung function indexes in the AECOPD group and the stable phase group were lower than those in the control group,and the AECOPD group was lower than the stable group(P<0.05).The serum levels of hs-CRP and TNF-αin patients with COPD were negatively correlated with FEV1 and FEV1/FVC values(r=-0.326,r=-0.635;r=-0.306,r=-0.511,P<0.05).Conclusion Combined detection of serum hs-CRP,TNF-αand pulmonary function can help to diagnose chronic obstructive pulmonary disease and determine the severity of chronic obstructive pulmonary disease,which will provide guidance for the early clinical treatment.