分析草酸艾司西酞普兰治疗抑郁症伴发睡眠障碍的临床疗效

Analyze the Clinical Efficacy of Escitalopram Oxalate in the Treatment of Depression with Sleep Disorder

目的探讨分析草酸艾司西酞普兰治疗抑郁症伴发睡眠障碍的临床疗效。方法选取医院精神科收治的抑郁症伴发睡眠障碍的患者380例,并将这380例患者利用随机数表法分为观察组和对照组。其中190例为对照组,为其给予阿戈美拉汀进行治疗,而观察组190例为其给予草酸艾司西酞普兰进行治疗,观察对比两组患者的治疗效果。结果经过对两组患者给予不同的治疗方式,观察组患者的总有效率(98.9%)明显高于对照组(57.9%),P<0.05;治疗前,观察组的HAMD与对照组差异无统计学意义,P>0.05,治疗后,观察组的HAMD分值明显低于对照组,P<0.05,数据差异具有统计学意义。结论临床治疗抑郁症伴发睡眠障碍患者最有效的治疗药物为草酸艾司西酞普兰,对于患者的睡眠改善与阿戈美拉汀效果相似,但是整体治疗效果明显优于阿戈美拉汀。

Objective To investigate and analyze the clinical efficacy of escitalopram oxalate in the treatment of depression with sleep disorders.Methods Three hundred and eighty patients with depression accompanied by sleep disorder in psychiatric department of hospital were selected,and 380 patients were divided into observation group and control group by random number table method.One hundred and ninety cases were treated with agomelatine as the control group,while 190 cases in the observation group were treated with escitalopram oxalate.The therapeutic effects of the two groups were observed and compared.Results The total effective rate of the observation group(98.9%)was significantly higher than that of the control group(57.9%)after different treatment methods were given to the two groups,P<0.05.Before treatment,there was no significant difference in HAMD between the observation group and the control group,P>0.05.After treatment,the HAMD score of the observation group was significantly lower than that of the control group,P<0.05.The data had statistical significance.Conclusion Escitalopram oxalate is the most effective drug for the treatment of depression patients with sleep disorders.The effect of ascitalopram on sleep improvement is similar to that of agomelatine,but the overall effect is significantly better than that of agomelatine.