ABCB1基因G2677T/A多态性与血脂水平及他汀类药物降脂效应关系的Meta分析

The role of ABCB1 G2677T/A polymorphisms in serum lipid levels and lipid-lowering response to statin treatment:a meta-analysis

目的评价ABCB1基因G2677T/A多态性与血脂水平及他汀类药物降脂效应的相关性。方法检索Pubmed、Cochrane Library、CNKI、VIP和万方数据库。采用MINORS量表对纳入的研究进行文献质量评价。用RevMan 5.3软件进行统计分析。结果共纳入10项独立研究,累计病人数3088例。Meta分析结果显示携带2677GG基因型与non⁃GG基因型、G non⁃G基因型或Non⁃G non⁃G基因型人群之间的血脂水平(TC、LDL⁃C、HDL⁃C及TG)差异无统计学意义,亦未发现这些不同组别人群之间他汀类药物降脂效应差异有统计学意义。结论基于研究结果,尚不能认为ABCB1基因G2677T/A多态性与血脂水平及他汀类药物降脂效应存在相关性。

Objective To evaluate the associations of ABCB1 G2677T/A polymorphisms with serum lipid levels and lipid⁃lowering response to statin treatment.Methods The Pubmed,Cochrane Library,CNKI,VIP and Wanfang database were retrieved according to the uniform retrieval strategy.MINORS scale was adopted to evaluate the quality of included studies.Statistical analysis was performed with RevMan 5.3 software.Results A total of 10 independent studies were included with a total of 3088 patients.The results of this meta⁃analysis showed that there was no statistically significant difference in serum lipid levels(TC,LDL⁃C,HDL⁃C and TG)between patients with the 2677GG genotypes and those with the non⁃GG genotypes,G non⁃G genotypes or the Non⁃G non⁃G genotypes,nor was there statistically significant difference in lipid lowering efficacy of statin treatment between these groups.Conclusion The current meta⁃analysis suggested that ABCB1 G2677T/A polymorphism is not associated with serum lipid levels and lipid⁃lower⁃ing response to statin treatment.