代谢组学在眼科中的研究进展

Research progress of metabolomics in ophthalmology

代谢组学属于系统生物学的一部分,对基因功能的阐述和生命体整体观的认识具有重要意义,其依赖磁共振波谱、质谱、色谱、光谱等分析化学技术来获取数据,检查标本通常为血浆、尿液、体液或者组织,已经广泛应用于基础生命科学、临床科学、药物研发和中医药等学科。眼科学方面的研究也逐渐增多,现就代谢组学的基本原理及在干眼症、角膜疾病、晶体疾病、青光眼、眼底疾病和视神经疾病等方面的成果进行系统综述。

Metabonomics is a part of system biology.It is of great significance to explain gene function and to understand the overall view of life.It relies on nuclear magnetic resonance spectroscopy,mass spectrometry,chromatography,spectroscopy and other analytical chemistry techniques to obtain data.The examination specimens are usually plasma,urine,body fluid or tissue.It has been widely used in basic life science,clinical science,drug research and development,traditional Chinese medicine and other disciplines.The research in ophthalmology is also gradually increasing.This article reviews the basic principles of metabonomics and its achievements in dry eye,corneal diseases,crystal diseases,glaucoma,fundus diseases and optic nerve diseases.