地奥心血康软胶囊联合常规西药治疗冠心病介入术后心绞痛的临床效果

Clinical effect of Di′ao Xinxuekang Soft Capsules combined with routine western medicine on angina pectoris after coronary intervention

目的观察地奥心血康软胶囊联合常规西药治疗冠心病介入术后心绞痛的临床效果。方法选取2017年4月~2019年1月西安交通大学医学院附属三二〇一医院收治的冠心病介入术后心绞痛患者123例,根据随机数字表法将患者分为对照组(n=61)和研究组(n=62)。所有患者入院后均给予常规治疗,嘱咐患者常规营养饮食、卧床休息、注意事项等。对照组给予常规西药治疗,研究组在对照组的基础上给予地奥心血康软胶囊。两组均连续治疗3个月。比较两组患者临床效果、心电图效果、血清学指标、生存质量、心绞痛发作情况及不良反应。结果研究组治疗后的临床效果、心电图总有效率均高于对照组,差异均有统计学意义(均P<0.05)。治疗前两组超氧化物岐化酶(SOD)、丙二醛(MDA)、超敏C反应蛋白(hs-CRP)水平比较,差异无统计学意义(P> 0.05)。治疗后两组MDA、hs-CRP水平低于治疗前,SOD水平高于治疗前;研究组MDA、hs-CRP水平低于对照组,SOD水平高于对照组,差异均有统计学意义(均P<0.05)。治疗前两组躯体活动受限、心绞痛稳定状态、治疗满意程度、心绞痛发作情况、疾病认识程度比较,差异无统计学意义(P> 0.05)。治疗后两组上述评分高于治疗前,且研究组高于对照组,差异均有统计学意义(均P<0.05)。治疗前两组心绞痛发作次数、持续时间比较,差异无统计学意义(P>0.05);治疗后两组心绞痛发作次数、持续时间低于治疗前,且研究组低于对照组,差异均有统计学意义(均P<0.05)。两组不良反应比较,差异无统计学意义(P> 0.05)。结论地奥心血康软胶囊联合常规西药治疗冠心病介入术后心绞痛,可迅速改善临床症状,效果确切,还可改善脂质过氧化物水平,降低炎性因子水平。

Objective To observe the clinical effect of Di’ao Xinxuekang Soft Capsules combined with routine western medicine on angina pectoris after coronary intervention.Methods From April 2017 to January 2019,123 cases with angina pectoris after coronary intervention were selected from 3201 Hospital Affiliated to Medical College of Xi’ an Jiaotong University.According to the random number table method,They were divided into control group(n=61) and study group(n=62).All patients were given routine treatment after admission,with instructions on routine nutrition diet,bed rest and precautions.Controls group was treated with routine western medicine treatment.Study group was given Di’ao Xinxuekang Soft Capsule on the basis of control group.Both groups were treated for 3 months.The clinical effect,electrocardiogram effect,serological index,quality of life,angina pectoris attack and adverse reactions of the two groups were compared.Results The total effective rate of clinical efficacy and electrocardiogram efficacy of study group after treatment were higher than those of control group,with statistically significant differences(all P <0.05).There was no significant difference in superoxide dismutase(SOD),malondialdehyde(MDA) and hypersensitive c-reactive protein(hs-CRP) levels in two groups before treatment(P> 0.05).After treatment,MDA and hs-CRP levels in two groups were lower than those before treatment,while SOD levels were higher than those before treatment.The levels of MDA and hs-CRP in study group were lower than those in control group,while the levels of SOD were higher than those in control group,with statistically significant differences(all P <0.05).Before treatment,there was no statistically significant difference between two groups in limited physical activity,stable angina pectoris,treatment satisfaction,angina pectoris attack and disease awareness(P> 0.05).The above scores in two groups after treatment were higher than those before treatment,and study group were higher than control group,with statistically significant differences(all P <0.05).There were no significant difference in the frequency and duration of angina pectoris between two groups before treatment(P> 0.05).After treatment,the frequency and duration of angina pectoris attacks in two groups were lower than those before treatment,and study group was lower than control group,with statistically significant differences(all P <0.05).There was no significant difference in adverse reactions between the two groups(P> 0.05).Conclusion Di’ao Xinxuekang Soft Capsule,combined with routine western medicine in the treatment of angina pectoris after coronary intervention can rapidly improve the clinical symptoms,the curative effect is definite.It can also improve the level of lipid peroxide and reduce inflammatory factors.