六味地黄丸辅助二甲双胍治疗2型糖尿病肾阴亏虚患者的临床效果分析

Efficacy of Liuwei Dihuang Wan plus dimethylbiguanide on type 2 diabetes of the Shenyin Kuixu type

目的:探讨六味地黄丸联合二甲双胍治疗2型糖尿病肾阴亏虚患者的临床疗效。方法:选取我院2015年1月-2018年1月诊断为2型糖尿病肾阴亏虚患者50例,随机数字法分为二甲双胍治疗组(对照组24例),六味地黄丸联合二甲双胍治疗组(观察组26例),疗程4周;比较两组患者临床疗效、总症状积分、糖化血红蛋白(HbA1c)、餐后2 h血糖值(2 hours Postprandial Blood Glucose,2 h PBG)、空腹血糖(Glucose,GLU)、血脂水平,检测其空腹胰岛素水平(Fasting Insulin,FINS)、观察胰岛素抵抗(HOMA-IR)情况,及24 h尿微量白蛋白水平(24 h MAU)、不良反应情况。结果:观察组临床疗效明显优于对照组(P<0.05);治疗后观察组临床症状评分均低于对照组(P<0.05);治疗后,观察组HbA1c、2 h PBG、GLU水平均低于对照组(P<0.05);观察组血脂水平较对照组改善更明显(P<0.05);观察组患者FINS水平、HOMA-IR及24 h MAU较对照组下降更显著(P<0.05);两组间不良反应比较无差别(P>0.05)。结论:六味地黄丸加减联合二甲双胍治疗肾阴亏虚型2型糖尿病患者效果显著,减轻患者临床症状,能改善患者血糖、血脂水平及胰岛素抵抗,并减轻糖尿病肾功能损害。

Objective:To investigate clinical efficacy of Liuwei Dihuang Wan(六味地黄丸)plus dimethylbiguanide on type 2 diabetes of the Shenyin Kuixu type(肾阴亏虚).Methods:From January 2015 to January 2018,50 cases were divided into two groups.24 cases in the control group was given dimethylbiguanide,and 26 cases in the observation group was given Liuwei Dihuang Wan more,for 4 weeks.Results:The clinical efficacy in the observation group was significantly better than that in the control group(P<0.05).After treatment,the clinical symptom scores in the observation group were lower than the control group(P<0.05).After treatment,the levels of HbA1c,2 h PBG and GLU in the observation group were lower than those in the control group(P<0.05).The blood lipid level in the observation group was significantly improved compared with the control group(P<0.05).The FINS level,HOMA-IR and 24 h MAU in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Liuwei Dihuang Wan plus dimethylbiguanide on type 2 diabetes of the Shenyin Kuixu type shows good effects,can improve blood sugar,blood lipid levels and insulin resistance,and reduce kidney damage in diabetic patients.