补液固膝方治疗轻中度老年原发性膝关节骨性关节炎的临床研究

Treating mild to moderate elderly primary knee osteoarthritis with the Buye Guxi decoction

目的:观察补液固膝方治疗轻中度老年原发性膝关节骨性关节炎(Knee Osteoarthritis,KOA)的临床疗效。方法:选取轻中度老年原发性KOA患者60例,随机分为两组,每组各30例,治疗组予补液固膝方,对照组予塞来昔布,疗程为4周,观察西安大略和麦克马斯特大学骨关节炎指数(The Western Ontario and McMaster Universities Osteoarthritis Index,WOMAC);并采用酶联免疫吸附测定法(Enzyme-Linked ImmunoSorbent Assay,ELISA),检测治疗前后患者血清Ⅱ型胶原交联羧基端肽(Cross Linked C-Telopeptide Of Type II Collagen,CTX-Ⅱ)和肿瘤坏死因子α(Tumor Necrosis Factor-α,TNF-α)水平。结果:治疗后治疗组TNF-α水平优于对照组,治疗后6个月时治疗组WOMAC评分优于对照组,组间比较差异均有统计学意义(P<0.05)。结论:补液固膝方治疗轻中度老年原发性膝关节骨性关节炎疗效优异。

Objective:To observe efficacy of the Buye Guxi decoction(补液固膝方)on mild to moderate elderly primary knee osteoarthritis.Methods:60 cases were divided into two groups,30 cases in each.The control group was given celecoxib;and the treatment group was given the Buye Guxi decoction,for 4 weeks.Results:After treatment,the TNF-αlevel in the treatment group was better than that in the control group.At 6 months after treatment,the WOMAC score in the treatment group was better than that in the control group(P<0.05).Conclusion:The Buye Guxi decoction on mild to moderate elderly primary knee osteoarthritis shows good effects.