宫颈癌患者术后人乳头状瘤病毒持续感染的危险因素分析

Analysis of risk factors of human papillomavirus persistent infection after radical hysterectomy

目的:分析宫颈癌患者术后人乳头状瘤病毒(Human papilloma virus,HPV)持续感染的危险因素。方法:在2017年1月至2019年6月期间于我院行腹腔镜根治性子宫切除术的宫颈癌患者中,随机选择术后发生HPV持续感染的60例患者(观察组)与术后未发生HPV持续感染的60例患者(对照组)进行回顾性研究。通过比较和分析两组患者的临床资料,包括年龄、宫颈癌家族史、绝经情况、阴道炎症感染、术前HPV感染亚型、HPV负荷量、吸烟史、饮酒史。分析宫颈癌患者术后发生HPV持续感染的危险因素。结果:经单因素、多因素Logistics回归分析,阴道炎症感染、术前HPV感染亚型、术前HPV负荷量、吸烟史是导致宫颈癌患者术后发生HPV持续感染的危险因素。结论:宫颈癌患者受到阴道炎症感染、术前HPV感染亚型、术前HPV负荷量、吸烟史等因素影响,其术后易发生HPV持续感染,临床上应根据其危险因素采取针对性预防措施。

Objective:To investigate the risk factors of human papilloma virus(HPV) persistent infection after radical hysterectomy. Methods: From January 2017 to June 2019, 60 patients with cervical cancer who underwent laparoscopic radical hysterectomy in our hospital with postoperative persistent infection of HPV were enrolled as the observation group. And 60 cases of patients without postoperative persistent infection of HPV were randomly selected as the control group for the retrospective study. The clinical characteristics of the two groups were compared, such as age, family history of cervical cancer, menopause, vaginitis infection, preoperative HPV infection subtype, HPV viral load, smoking history, drinking history. And the risk factors of postoperative persistent infection of HPV were analyzed. Results: According to the logistic regression analysis of single factor and multiple factors,the infection of vaginitis, the subtype of HPV infection before operation, the viral load of HPV before operation and the smoking history were the risk factors for the persistent infection of HPV after operation. Conclusion:Pre-operative HPV infection subtype, pre-operative HPV viral load, and smoking history are risk factors of persistent HPV infection after operation.